Synthesis and preliminary evaluation of duocarmycin analogues incorporating the 1,2,11,11a-tetrahydrocyclopropa c naphtho 2,3-e indol-4-one (CNI) and 1,2,11,11a-tetrahydrocyclopropa c naphtho 1,2-e indol-4-one (iso-CNI) alkylation subunits

Academic Article
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publication date

  • August 2009

abstract

  • Efficient syntheses and a preliminary evaluation of 1,2,11,11a-tetrahydrocyclopropa[c]-naphtho[2,3-e]indole (CNI) and 1,2,11,11a-tetrahydrocyclopropa[c]naphtho[1,2-e]indole (iso-CNI), and their derivatives containing an anthracene and phenanthrene variant of the CC-1065 or duocarmycin alkylation subunit are detailed.