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Synthesis and preliminary evaluation of duocarmycin analogues incorporating the 1,2,11,11a-tetrahydrocyclopropa c naphtho 2,3-e indol-4-one (CNI) and 1,2,11,11a-tetrahydrocyclopropa c naphtho 1,2-e indol-4-one (iso-CNI) alkylation subunits

Academic Article
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Overview

related to degree

  • Macmillan, Karen Smith, Ph.D. in Chemistry, Scripps Research 2004 - 2009

authors

  • Gauss, C. M.
  • Hamasaki, A.
  • Parrish, J. P.
  • Macmillan, Karen Smith
  • Rayl, T. J.
  • Hwang, I.
  • Boger, Dale

publication date

  • August 2009

journal

  • Tetrahedron  Journal

abstract

  • Efficient syntheses and a preliminary evaluation of 1,2,11,11a-tetrahydrocyclopropa[c]-naphtho[2,3-e]indole (CNI) and 1,2,11,11a-tetrahydrocyclopropa[c]naphtho[1,2-e]indole (iso-CNI), and their derivatives containing an anthracene and phenanthrene variant of the CC-1065 or duocarmycin alkylation subunit are detailed.
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Identity

PubMed Central ID

  • PMC2713043

International Standard Serial Number (ISSN)

  • 0040-4020

Digital Object Identifier (DOI)

  • 10.1016/j.tet.2009.02.065

PubMed ID

  • 20161204
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Additional Document Info

start page

  • 6591

end page

  • 6599

volume

  • 65

issue

  • 33

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