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Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics

Academic Article
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Overview

authors

  • Swerdlow, N. R.
  • Braff, D. L.
  • Geyer, M. A.
  • Koob, George

publication date

  • January 1986

journal

  • Biological Psychiatry  Journal

abstract

  • Schizophrenic patients show loss of the normal inhibition of the acoustic startle response (ASR) when the startle stimulus is preceded by a weak prepulse stimulus. In rats experimentally induced to have locally supersensitive dopamine receptors within forebrain dopamine terminal regions, we find a similar deficit in "prepulse inhibition" of the ASR. Our results suggest that there are intriguing parallels between the aberrant sensory gating of the ASR demonstrated by schizophrenics and that demonstrated by rats during stimulation of supersensitive brain dopamine receptors. Thus, prepulse inhibition of the ASR provides a useful paradigm for investigating the bridge between mesolimbic dopamine overactivity and the specific time-dependent information processing-sensory gating disturbances that have been identified in schizophrenic patients.

subject areas

  • Acoustic Stimulation
  • Animals
  • Brain Chemistry
  • Disease Models, Animal
  • Hydroxydopamines
  • Male
  • Oxidopamine
  • Rats
  • Rats, Inbred Strains
  • Receptors, Dopamine
  • Reflex, Startle
  • Schizophrenia
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Identity

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(86)90005-3

PubMed ID

  • 3080033
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Additional Document Info

start page

  • 23

end page

  • 33

volume

  • 21

issue

  • 1

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