recent publications
-
academic article
- Zhuang, L., Hulin, J. A., Gromova, A., Nguyen, T. D. T., Yu, R. T., Liddle, C., Downes, M., Evans, R. M., Makarenkova, H. P., Meech, R. Barx2 and Pax7 have antagonistic functions in regulation of wnt signaling and satellite cell differentiation Stem Cells 2014 32:1661-1673 DOI:10.1002/stem.1674 PMID:24753152 PMCID:PMC4134105
- Panopoulos, A. D., Yanes, O., Ruiz, S., Kida, Y. S., Diep, D., Tautenhahn, R., Herrerias, A., Batchelder, E. M., Plongthongkum, N., Lutz, M., Berggren, W. T., Zhang, K., et al. The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming Cell Research 2012 22:168-177 DOI:10.1038/cr.2011.177 PMID:22064701 PMCID:PMC3252494
- Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., Evans, R. M. Cryptochromes mediate rhythmic repression of the glucocorticoid receptor Nature 2011 480:552-556 DOI:10.1038/nature10700 PMID:22170608 PMCID:PMC3245818
- Krebs, P., Fan, W. W., Chen, Y. H., Tobita, K., Downes, M. R., Wood, M. R., Sun, L., Li, X. H., Xia, Y., Ding, N., Spaeth, J. M., Moresco, E. M. Y., et al. Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet Proceedings of the National Academy of Sciences of the United States of America 2011 108:19678-19682 DOI:10.1073/pnas.1117835108 PMID:22106289 PMCID:PMC3241770
- Lamia, K. A., Evans, R. M. Metabolism: Tick, tock, a beta-cell clock Nature 2010 466:571-572 DOI:10.1038/466571a PMID:20671699 PMCID:PMC3610560
- Lamia, K. A., Sachdeva, U. M., DiTacchio, L., Williams, E. C., Alvarez, J. G., Egan, D. F., Vasquez, D. S., Juguilon, H., Panda, S., Shaw, R. J., Thompson, C. B., Evans, R. M. AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation Science 2009 326:437-440 DOI:10.1126/science.1172156 PMID:19833968 PMCID:PMC2819106
- Barish, G. D., Atkins, A. R., Downes, M., Olson, P., Chong, L. W., Nelson, M., Zou, Y., Hwang, H., Kang, H., Curtiss, L., Evans, R. M., Lee, C. H. PPAR delta regulates multiple proinflammatory pathways to suppress atherosclerosis Proceedings of the National Academy of Sciences of the United States of America 2008 105:4271-4276 DOI:10.1073/pnas.0711875105 PMID:18337509 PMCID:PMC2393796
- Wan, Y. H., Saghatelian, A., Chong, L. W., Zhang, C. L., Cravatt, B. F., Evans, R. M. Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk Genes & Development 2007 21:1895-1908 DOI:10.1101/gad.1567207 PMID:17652179 PMCID:PMC1935028
- Yang, X., Lamia, K. A., Evans, R. M. Nuclear receptors, metabolism, and the circadian clock Cold Spring Harbor Symposia on Quantitative Biology 2007 72:387-394 DOI:10.1101/sqb.2007.72.058 PMID:18419296
- Qi, L., Heredia, J. E., Altarejos, J. Y., Screaton, R., Goebel, N., Niessen, S., MacLeod, I. X., Liew, C. W., Kulkarni, R. N., Bain, J., Newgard, C., Nelson, M., et al. TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism Science 2006 312:1763-1766 DOI:10.1126/science.1123374 PMID:16794074
- Li, Z., Chen, W. R., Hale, J. J., Lynch, C. L., Mills, S. G., Hajdu, R., Keohane, C. A., Rosenbach, M. J., Milligan, J. A., Shei, G. J., Chrebet, G., Parent, S. A., et al. Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (s1p(1)) receptor agonists with exceptional selectivity against s1p(2) and s1p(3) Journal of Medicinal Chemistry 2005 48:6169-6173 DOI:10.1021/jm0503244 PMID:16190743
- Galimi, F., Saez, E., Gall, J., Hoong, N., Cho, G., Evans, R. M., Verma, I. M. Development of ecdysone-regulated lentiviral vectors Molecular Therapy 2005 11:142-148 DOI:10.1016/j.ymthe.2004.08.021 PMID:15585415
- Saez, E., Rosenfeld, J., Livolsi, A., Olson, P., Lombardo, E., Nelson, M., Banayo, E., Cardiff, R. D., Izpisua-Belmonte, J. C., Evans, R. M. Ppar gamma signaling exacerbates mammary gland tumor development Genes & Development 2004 18:528-540 DOI:10.1101/gad.1167804 PMID:15037548 PMCID:PMC374235
- Xu, W., Cho, H., Kadam, S., Banayo, E. M., Anderson, S., Yates, J. R., Emerson, B. M., Evans, R. M. A methylation-mediator complex in hormone signaling Genes & Development 2004 18:144-156 DOI:10.1101/gad.1141704 PMID:14729568 PMCID:PMC324421
- Demarest, S. J., Deechongkit, S., Dyson, H. J., Evans, R. M., Wright, P. E. Packing, specificity, and mutability at the binding interface between the p160 coactivator and creb-binding protein Protein Science 2004 13:203-210 DOI:10.1110/ps.03366504 PMID:14691235 PMCID:PMC2286511
- Saez, E., Olson, P., Evans, R. M. Genetic deficiency in pparg does not alter development of experimental prostate cancer Nature Medicine 2003 9:1265-1266 DOI:10.1038/nm928 PMID:12960963
- Gearhart, M. D., Holmbeck, S. M. A., Evans, R. M., Dyson, H. J., Wright, P. E. Monomeric complex of human orphan estrogen related receptor-2 with DNA: A pseudo-dimer interface mediates extended half-site recognition Journal of Molecular Biology 2003 327:819-832 DOI:10.1016/s0022-2836(03)00183-9 PMID:12654265
- Downes, M., Verdecia, M. A., Roecker, A. J., Hughes, R., Hogenesch, J. B., Kast-Woelbern, H. R., Bowman, M. E., Ferrer, J. L., Anisfeld, A. M., Edwards, P. A., Rosenfeld, J. M., Alvarez, J. G. A., et al. A chemical, genetic, and structural analysis of the nuclear bile acid receptor fxr Molecular Cell 2003 11:1079-1092 DOI:10.1016/s1097-2765(03)00104-7 PMID:12718892
- Nicolaou, K. C., Evans, R. M., Roecker, A. J., Hughes, R., Downes, M., Pfefferkorn, J. A. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries Organic & Biomolecular Chemistry 2003 1:908-920 DOI:10.1039/b300525a PMID:12929628
- Demarest, S. J., Martinez-Yamout, M., Chung, J., Chen, H. W., Xu, W., Dyson, H. J., Evans, R. M., Wright, P. E. Mutual synergistic folding in recruitment of cbp/p300 by p160 nuclear receptor coactivators Nature 2002 415:549-553 DOI:10.1038/415549a PMID:11823864
- Xu, W., Chen, H. W., Du, K. Y., Asahara, H., Tini, M., Emerson, B. M., Montminy, M., Evans, R. M. A transcriptional switch mediated by cofactor methylation Science 2001 294:2507-2511 DOI:10.1126/science.1065961 PMID:11701890
- Chawla, A., Boisvert, W. A., Lee, C. H., Laffitte, B. A., Barak, Y., Joseph, S. B., Liao, D., Nagy, L., Edwards, P. A., Curtiss, L. K., Evans, R. M., Tontonoz, P. A ppar gamma-lxr-abca1 pathway in macrophages is involved in cholesterol efflux and atherogenesis Molecular Cell 2001 7:161-171 DOI:10.1016/s1097-2765(01)00164-2 PMID:11172721
- Saez, E., Nelson, M. C., Eshelman, B., Banayo, E., Koder, A., Cho, G. J., Evans, R. M. Identification of ligands and coligands for the ecdysone-regulated gene switch Proceedings of the National Academy of Sciences of the United States of America 2000 97:14512-14517 DOI:10.1073/pnas.260499497 PMID:11114195 PMCID:PMC18950
- Chawla, A., Saez, E., Evans, R. M. "Don't know much bile-ology" Cell 2000 103:1-4 DOI:10.1016/s0092-8674(00)00097-0 PMID:11051540
- Asahara, H., Dutta, S., Kao, H. Y., Evans, R. M., Montminy, M. Pbx-hox heterodimers recruit coactivator-corepressor complexes in an isoform-specific manner Molecular and Cellular Biology 1999 19:8219-8225 PMID:10567547 PMCID:PMC84906
- Saez, E., Tontonoz, P., Nelson, M. C., Alvarez, J. G. A., U, T. M., Baird, S. M., Thomazy, V. A., Evans, R. M. Activators of the nuclear receptor ppar gamma enhance colon polyp formation Nature Medicine 1998 4:1058-1061 DOI:10.1038/2042 PMID:9734400
- Saez, E., No, D., West, A., Evans, R. M. Inducible gene expression in mammalian cells and transgenic mice Current Opinion in Biotechnology 1997 8:608-616 DOI:10.1016/s0958-1669(97)80037-7 PMID:9353233
- Sem, D. S., Casimiro, D. R., Kliewer, S. A., Provencal, J., Evans, R. M., Wright, P. E. Nmr spectroscopic studies of the DNA-binding domain of the monomer-binding nuclear orphan receptor, human estrogen related receptor-2 - the carboxyl-terminal extension to the zinc-finger region is unstructured in the free form of the protein Journal of Biological Chemistry 1997 272:18038-18043 DOI:10.1074/jbc.272.29.18038 PMID:9218433
- Lee, M. S., Sem, D. S., Kliewer, S. A., Provencal, J., Evans, R. M., Wright, P. E. Nmr assignments and secondary structure of the retinoid-x receptor-alpha DNA-binding domain - evidence for the novel c-terminal helix European Journal of Biochemistry 1994 224:639-650 DOI:10.1111/j.1432-1033.1994.00639.x PMID:7925381
- Lee, M. S., Kliewer, S. A., Provencal, J., Wright, P. E., Evans, R. M. Structure of the retinoid-x receptor-alpha DNA-binding domain - a helix required for homodimeric DNA-binding Science 1993 260:1117-1121 DOI:10.1126/science.8388124 PMID:8388124