recent publications

• academic article

  • Cheng, B. Y. H., Ortiz-Riano, E., de la Torre, J. C., Martinez-Sobrido, L. Arenavirus genome rearrangement for the development of live attenuated vaccines Journal of Virology  2015 89:7373-7384  DOI:10.1128/jvi.00307-15  PMID:25972555  PMCID:PMC4473541
  • Pythoud, C., Rothenberger, S., Martinez-Sobrido, L., de la Torre, J. C., Kunz, S. Lymphocytic choriomeningitis virus differentially affects the virus-induced type I interferon response and mitochondrial apoptosis mediated by RIG-I/MAVS Journal of Virology  2015 89:6240-6250  DOI:10.1128/jvi.00610-15  PMID:25833049
  • Cheng, B. Y. H., Ortiz-Riano, E., Nogales, A., de la Torre, J. C., Martinez-Sobrido, L. Development of live-attenuated arenavirus vaccines based on codon deoptimization Journal of Virology  2015 89:3523-3533  DOI:10.1128/jvi.03401-14  PMID:25589652
  • Ortiz-Riano, E., Ngo, N., Devito, S., Eggink, D., Munger, J., Shaw, M. L., de la Torre, J. C., Martinez-Sobrido, L. Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor Journal of Virology  2014 88:878-889  DOI:10.1128/jvi.02275-13  PMID:24198417  PMCID:PMC3911634
  • Ortiz-Riano, E., Cheng, B. Y. H., de la Torre, J. C., Martinez-Sobrido, L. Arenavirus reverse genetics for vaccine development Journal of General Virology  2013 94:1175-1188  DOI:10.1099/vir.0.051102-0  PMID:23364194  PMCID:PMC3709625
  • Ortiz-Riano, E., Cheng, B. Y. H., de la Torre, J. C., Martinez-Sobrido, L. D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis Viruses-Basel  2012 4:2137-2161  DOI:10.3390/v4102137  PMID:23202457  PMCID:PMC3497045
  • Pythoud, C., Rodrigo, Wwsi, Pasqual, G., Rothenberger, S., Martinez-Sobrido, L., de la Torre, J. C., Kunz, S. Arenavirus nucleoprotein targets interferon regulatory factor-activating kinase IKK epsilon Journal of Virology  2012 86:7728-7738  DOI:10.1128/jvi.00187-12  PMID:22532683  PMCID:PMC3421673
  • Rodrigo, Wwsi, Ortiz-Riano, E., Pythoud, C., Kunz, S., de la Torre, J. C., Martinez-Sobrido, L. Arenavirus nucleoproteins prevent activation of nuclear factor kappa b Journal of Virology  2012 86:8185-8197  DOI:10.1128/jvi.07240-11  PMID:22623788  PMCID:PMC3421694
  • Ortiz-Riano, E., Cheng, B. Y. H., de la Torre, J. C., Martinez-Sobrido, L. Self-association of lymphocytic choriomeningitis virus nucleoprotein is mediated by its N-terminal region and is not required for its anti-interferon function Journal of Virology  2012 86:3307-3317  DOI:10.1128/jvi.05503-11  PMID:22258244  PMCID:PMC3302321
  • Ortiz-Riano, E., Cheng, B. Y. H., de la Torre, J. C., Martinez-Sobrido, L. The C-terminal region of lymphocytic choriomeningitis virus nucleoprotein contains distinct and segregable functional domains involved in NP-Z interaction and counteraction of the type I interferon response Journal of Virology  2011 85:13038-13048  DOI:10.1128/jvi.05834-11  PMID:21976642  PMCID:PMC3233175
  • Rodrigo, Wwsi, de la Torre, J. C., Martinez-Sobrido, L. Use of single-cycle infectious lymphocytic choriomeningitis virus to study hemorrhagic fever arenaviruses Journal of Virology  2011 85:1684-1695  DOI:10.1128/jvi.02229-10  PMID:21123370  PMCID:PMC3028880
  • Borrow, P., Martinez-Sobrido, L., de la Torre, J. C. Inhibition of the type I interferon antiviral response during arenavirus infection Viruses-Basel  2010 2:2443-2480  DOI:10.3390/v2112443  PMID:21994626  PMCID:PMC3185579
  • Martinez-Sobrido, L., Emonet, S., Giannakas, P., Cubitt, B., Garcia-Sastre, A., de la Torre, J. C. Identification of amino acid residues critical for the anti-interferon activity of the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus Journal of Virology  2009 83:11330-11340  DOI:10.1128/jvi.00763-09  PMID:19710144  PMCID:PMC2772779
  • Martinez-Sobrido, L., Giannakas, P., Cubitt, B., Garcia-Sastre, A., de la Torre, J. C. Differential inhibition of type I interferon induction by arenavirus nucleoproteins Journal of Virology  2007 81:12696-12703  DOI:10.1128/jvi.00882-07  PMID:17804508
  • Martinez-Sobrido, L., Zuniga, E. I., Rosario, D., Garcia-Sastre, A., de la Torre, J. C. Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus Journal of Virology  2006 80:9192-9199  DOI:10.1128/jvi.00555-06  PMID:16940530
  • Cardenas, W. B., Loo, Y. M., Gale, M., Hartman, A. L., Kimberlin, C. R., Martinez-Sobrido, L., Saphire, E. O., Basler, C. F. Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling Journal of Virology  2006 80:5168-5178  DOI:10.1128/jvi.02199-05  PMID:16698997