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Intermolecular Ritter-type C-H amination of unactivated sp3 carbons

Academic Article
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Overview

related to degree

  • Michaudel, Quentin, Ph.D. in Organic Chemistry, Scripps Research 2010 - 2015

authors

  • Michaudel, Quentin
  • Thevenet, D.
  • Baran, Phil

publication date

  • 2012

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Intermolecular Ritter-type C-H amination of unactivated sp(3) carbons has been developed. This new reaction proceeds under mild conditions using readily available reagents and an inexpensive source of nitrogen (acetonitrile). A broad scope of substrates can be aminated with this method since many functional groups are tolerated. This reaction also allows for the direct, innate C-H amination of a variety of hydrocarbons such as cyclohexane without the need of prefunctionalization or installation of a directing group.

subject areas

  • Alcohols
  • Amides
  • Amination
  • Amines
  • Hydrocarbons
  • Ketones
  • Molecular Structure
  • Stereoisomerism
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Identity

PubMed Central ID

  • PMC3277284

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja212020b

PubMed ID

  • 22276612
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Additional Document Info

start page

  • 2547

end page

  • 2550

volume

  • 134

issue

  • 5

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