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Lymphocyte-activation by monovalent fragments of antibodies reactive with cell-surface carbohydrates

Academic Article
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Overview

authors

  • Sela, B. A.
  • Wang, J. L.
  • Edelman, Gerald

publication date

  • 1976

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Antibodies reactive with cell surface carbohydrates were isolated from normal chicken serum and were found to be mitogenic for mouse splenic lymphocytes as assayed by both blast transformation and [3H]thymidine incorporation. The Fab' fragments of these carbohydrate-binding immunoglobulins were just as mitogenic as the divalent native antibody. Moreover, succinylated Fab' fragments, which probably would not form self-associating aggregates, showed similar mitogenic properties. All of these results indicate that, at least for saccharide-specific ligands, multipoint attachment and receptor cross-linkage on the cell to which the ligand is attached may not be a stringent requirement for activation.

subject areas

  • Animals
  • Binding Sites, Antibody
  • Carbohydrates
  • Cell Membrane
  • Chickens
  • Cross Reactions
  • Immunoglobulin Fab Fragments
  • Immunoglobulin Fragments
  • Lymphocyte Activation
  • Mice
  • Mitogens
  • Spleen
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Identity

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.143.3.665

PubMed ID

  • 1249523
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Additional Document Info

start page

  • 665

end page

  • 671

volume

  • 143

issue

  • 3

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