Base-pairing systems related to TNA: alpha-threofuranosyl oligonucleotides containing phosphoramidate linkages

Academic Article
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publication date

  • April 2002

abstract

  • (3'NH)- and (2'NH)-TNA, two isomeric phosphoramidate analogues of TNA (alpha-threofuranosyl-(3'-->2') oligonucleotides), are shown to be efficient Watson-Crick base-pairing systems and to undergo intersystem cross-pairing with TNA, RNA, and DNA. [reaction: see text]