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Base-pairing systems related to TNA: alpha-threofuranosyl oligonucleotides containing phosphoramidate linkages

Academic Article
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Overview

authors

  • Wu, X.
  • Guntha, S.
  • Ferencic, M.
  • Krishnamurthy, Ramanarayanan
  • Eschenmoser, A.

publication date

  • April 2002

journal

  • Organic Letters  Journal

abstract

  • (3'NH)- and (2'NH)-TNA, two isomeric phosphoramidate analogues of TNA (alpha-threofuranosyl-(3'-->2') oligonucleotides), are shown to be efficient Watson-Crick base-pairing systems and to undergo intersystem cross-pairing with TNA, RNA, and DNA. [reaction: see text]

subject areas

  • Amides
  • Base Pairing
  • Chromatography, High Pressure Liquid
  • Circular Dichroism
  • DNA
  • Furans
  • Indicators and Reagents
  • Oligonucleotides
  • Phosphoric Acids
  • RNA
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
  • Spectrophotometry, Ultraviolet
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Identity

International Standard Serial Number (ISSN)

  • 1523-7060

Digital Object Identifier (DOI)

  • 10.1021/ol020015x

PubMed ID

  • 11950342
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Additional Document Info

start page

  • 1279

end page

  • 1282

volume

  • 4

issue

  • 8

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