Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Molecular mechanism for switching of p-falciparum invasion pathways into human erythrocytes

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Stubbs, J.
  • Simpson, K. M.
  • Triglia, T.
  • Plouffe, D.
  • Tonkin, C. J.
  • Duraisingh, M. T.
  • Maier, A. G.
  • Winzeler, Elizabeth
  • Cowman, A. F.

publication date

  • August 2005

journal

  • Science  Journal

abstract

  • The malaria parasite, Plasmodium falciparum, exploits multiple ligand-receptor interactions, called invasion pathways, to invade the host erythrocyte. Strains of P. falciparum vary in their dependency on sialated red cell receptors for invasion. We show that switching from sialic acid-dependent to -independent invasion is reversible and depends on parasite ligand use. Expression of P. falciparum reticulocyte-binding like homolog 4 (PfRh4) correlates with sialic acid-independent invasion, and PfRh4 is essential for switching invasion pathways. Differential activation of PfRh4 represents a previously unknown mechanism to switch invasion pathways and provides P. falciparum with exquisite adaptability in the face of erythrocyte receptor polymorphisms and host immune responses.

subject areas

  • Animals
  • Animals, Genetically Modified
  • Erythrocytes
  • Gene Expression Profiling
  • Gene Silencing
  • Genes, Protozoan
  • Humans
  • Ligands
  • Membrane Proteins
  • Neuraminidase
  • Oligonucleotide Array Sequence Analysis
  • Plasmodium falciparum
  • Polymerase Chain Reaction
  • Protozoan Proteins
  • Recombinant Fusion Proteins
  • Sialic Acids
  • Transcription, Genetic
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1115257

PubMed ID

  • 16123303
scroll to property group menus

Additional Document Info

start page

  • 1384

end page

  • 1387

volume

  • 309

issue

  • 5739

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support