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Nucleic acid structure and recognition

Academic Article
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Overview

authors

  • Duckett, Derek
  • Murchie, A. I. H.
  • Clegg, R. M.
  • Bassi, G. S.
  • Giraud-Panis, M. J. E.
  • Lilley, D. M. J.

publication date

  • October 1997

journal

  • Biophysical Chemistry  Journal

abstract

  • We review the global structures adopted by branched nucleic acids, including three- and four-way helical junctions in DNA and RNA. We find that some general folding principles emerge. First, all the structures exhibit a tendency to undergo pairwise coaxial helical stacking when permitted by the local stereochemistry of strand exchange. Second, metal ions generally play an important role in facilitating folding of branched nucleic acids. These principles can be applied to functionally important branched nucleic acids, such as the Holliday DNA junction of genetic recombination, and the hammerhead ribozyme in RNA.
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Identity

International Standard Serial Number (ISSN)

  • 0301-4622

Digital Object Identifier (DOI)

  • 10.1016/s0301-4622(97)00007-0

PubMed ID

  • 17029905
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Additional Document Info

start page

  • 53

end page

  • 62

volume

  • 68

issue

  • 1-3

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