recent publications

• academic article

  • Kallupi, M., Cannella, N., Economidou, D., Ubaldi, M., Ruggeri, B., Weiss, F., Massi, M., Marugan, J., Heilig, M., Bonnavion, P., de Lecea, L., Ciccocioppo, R. Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system Proceedings of the National Academy of Sciences of the United States of America  2010 107:19567-19572  DOI:10.1073/pnas.1004100107  PMID:20974945  PMCID:PMC2984152
  • Paneda, C., Huitron-Resendiz, S., Frago, L. M., Chowen, J. A., Picetti, R., de Lecea, L., Roberts, A. J. Neuropeptide s reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice Journal of Neuroscience  2009 29:4155-4161  DOI:10.1523/jneurosci.5256-08.2009  PMID:19339610  PMCID:PMC3437665
  • Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L., Bartfai, T. Transgenic mice with a reduced core body temperature have an increased life span Science  2006 314:825-828  DOI:10.1126/science.1132191  PMID:17082459
  • Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., de Lecea, L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior Proceedings of the National Academy of Sciences of the United States of America  2005 102:19168-19173  DOI:10.1073/pnas.0507480102  PMID:16357203  PMCID:PMC1323172
  • Tallent, M. K., Veronique, F., Qiu, C., Calbet, M., Lamp, T., Baratta, M. V., Suzuki, C., Levy, C. L., Siggins, G. R., Henriksen, S. J., Criado, J. R., Roberts, A., et al. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning Molecular and Cellular Neuroscience  2005 30:465-475  DOI:10.1016/j.mcn.2005.08.010  PMID:16182561
  • de Lecea, L., Sutcliffe, J. G. The hypocretins and sleep FEBS Journal  2005 272:5675-5688  DOI:10.1111/j.1742-4658.2005.04981.x  PMID:16279933
  • Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., de Lecea, L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): A novel circuit mediating stress response Journal of Neuroscience  2004 24:11439-11448  DOI:10.1523/jneurosci.3459-04.2004  PMID:15601950
  • Martin, G., Guadano-Ferraz, A., Morte, B., Ahmed, S., Koob, G. F., de Lecea, L., Siggins, G. R. Chronic morphine treatment alters n-methyl-d-aspartate receptors in freshly isolated neurons from nucleus accumbens Journal of Pharmacology and Experimental Therapeutics  2004 311:265-273  DOI:10.1124/jpet.104.067504  PMID:15263066
  • Krucker, T., Siggins, G. R., McNamara, R. K., Lindsley, K. A., Dao, A., Allison, D. W., de Lecea, L., Lovenberg, T. W., Sutcliffe, J. G., Gerendasy, D. D. Targeted disruption of rc3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus Journal of Neuroscience  2002 22:5525-5535  PMID:12097504
  • Sutcliffe, J. G., de Lecea, L. The hypocretins: Setting the arousal threshold Nature Reviews Neuroscience  2002 3:339-349  DOI:10.1038/nrn808  PMID:11988773
  • de Lecea, L., Sutcliffe, J. G., Fabre, V. Hypocretins/orexins as integrators of physiological information: Lessons from mutant animals Neuropeptides  2002 36:85-95  DOI:10.1054/npep.2002.0892  PMID:12359500
  • Martin, G., Fabre, W., Siggins, G. R., de Lecea, L. Interaction of the hypocretins with neurotransmitters in the nucleus accumbens Regulatory Peptides  2002 104:111-117  DOI:10.1016/s0167-0115(01)00354-8  PMID:11830285
  • Bourgin, P., Huitron-Resendiz, S., Spier, A. D., Fabre, V., Morte, B., Criado, J. R., Sutcliffe, J. G., Henriksen, S. J., de Lecea, L. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons Journal of Neuroscience  2000 20:7760-7765  PMID:11027239
  • Sutcliffe, J. G., de Lecea, L. The hypocretins: Excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding Journal of Neuroscience Research  2000 62:161-168  DOI:10.1002/1097-4547(20001015)62:2<161::aid-jnr1>3.0.co;2-1  PMID:11020209
  • de Lecea, L., Sutcliffe, J. G. The hypocretins/orexins: Novel hypothalamic neuropeptides involved in different physiological systems Cellular and Molecular Life Sciences  1999 56:473-480  DOI:10.1007/s000180050446  PMID:11212299
  • Calbet, M., Guadano-Ferraz, A., Spier, A. D., Maj, M., Sutcliffe, J. G., Przewlocki, R., de Lecea, L. Cortistatin and somatostatin mrnas are differentially regulated in response to kainate Molecular Brain Research  1999 72:55-64  DOI:10.1016/s0169-328x(99)00220-x  PMID:10521599
  • Hakansson, M. L., de Lecea, L., Sutcliffe, J. G., Yanagisawa, M., Meister, B. Leptin receptor- and stat3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus Journal of Neuroendocrinology  1999 11:653-663  PMID:10447804
  • Criado, J. R., Li, H. T., Jiang, X. H., Spina, M., Huitron-Resendiz, S., Liapakis, G., Calbet, M., Siehler, S., Henriksen, S. J., Koob, G., Hoyer, D., Sutcliffe, J. G., et al. Structural and compositional determinants of cortistatin activity Journal of Neuroscience Research  1999 56:611-619  DOI:10.1002/(sici)1097-4547(19990615)56:6<611::aid-jnr7>3.0.co;2-g  PMID:10374816
  • Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., Kilduff, T. S. Neurons containing hypocretin (orexin) project to multiple neuronal systems Journal of Neuroscience  1998 18:9996-10015  PMID:9822755
  • de Lecea, L., Criado, J. R., Rivera, S., Wen, W., Soriano, E., Henriksen, S. J., Taylor, S. S., Gall, C. M., Sutcliffe, J. G. Endogenous protein kinase a inhibitor (pki alpha) modulates synaptic activity Journal of Neuroscience Research  1998 53:269-278  DOI:10.1002/(sici)1097-4547(19980801)53:3<269::aid-jnr1>3.0.co;2-8  PMID:9698155