recent publications
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academic article
- Kallupi, M., Cannella, N., Economidou, D., Ubaldi, M., Ruggeri, B., Weiss, F., Massi, M., Marugan, J., Heilig, M., Bonnavion, P., de Lecea, L., Ciccocioppo, R. Neuropeptide S facilitates cue-induced relapse to cocaine seeking through activation of the hypothalamic hypocretin system Proceedings of the National Academy of Sciences of the United States of America 2010 107:19567-19572 DOI:10.1073/pnas.1004100107 PMID:20974945 PMCID:PMC2984152
- Paneda, C., Huitron-Resendiz, S., Frago, L. M., Chowen, J. A., Picetti, R., de Lecea, L., Roberts, A. J. Neuropeptide s reinstates cocaine-seeking behavior and increases locomotor activity through corticotropin-releasing factor receptor 1 in mice Journal of Neuroscience 2009 29:4155-4161 DOI:10.1523/jneurosci.5256-08.2009 PMID:19339610 PMCID:PMC3437665
- Conti, B., Sanchez-Alavez, M., Winsky-Sommerer, R., Morale, M. C., Lucero, J., Brownell, S., Fabre, V., Huitron-Resendiz, S., Henriksen, S., Zorrilla, E. P., de Lecea, L., Bartfai, T. Transgenic mice with a reduced core body temperature have an increased life span Science 2006 314:825-828 DOI:10.1126/science.1132191 PMID:17082459
- Boutrel, B., Kenny, P. J., Specio, S. E., Martin-Fardon, R., Markou, A., Koob, G. F., de Lecea, L. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior Proceedings of the National Academy of Sciences of the United States of America 2005 102:19168-19173 DOI:10.1073/pnas.0507480102 PMID:16357203 PMCID:PMC1323172
- Tallent, M. K., Veronique, F., Qiu, C., Calbet, M., Lamp, T., Baratta, M. V., Suzuki, C., Levy, C. L., Siggins, G. R., Henriksen, S. J., Criado, J. R., Roberts, A., et al. Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning Molecular and Cellular Neuroscience 2005 30:465-475 DOI:10.1016/j.mcn.2005.08.010 PMID:16182561
- de Lecea, L., Sutcliffe, J. G. The hypocretins and sleep FEBS Journal 2005 272:5675-5688 DOI:10.1111/j.1742-4658.2005.04981.x PMID:16279933
- Winsky-Sommerer, R., Yamanaka, A., Diano, S., Borok, E., Roberts, A. J., Sakurai, T., Kilduff, T. S., Horvath, T. L., de Lecea, L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): A novel circuit mediating stress response Journal of Neuroscience 2004 24:11439-11448 DOI:10.1523/jneurosci.3459-04.2004 PMID:15601950
- Martin, G., Guadano-Ferraz, A., Morte, B., Ahmed, S., Koob, G. F., de Lecea, L., Siggins, G. R. Chronic morphine treatment alters n-methyl-d-aspartate receptors in freshly isolated neurons from nucleus accumbens Journal of Pharmacology and Experimental Therapeutics 2004 311:265-273 DOI:10.1124/jpet.104.067504 PMID:15263066
- Krucker, T., Siggins, G. R., McNamara, R. K., Lindsley, K. A., Dao, A., Allison, D. W., de Lecea, L., Lovenberg, T. W., Sutcliffe, J. G., Gerendasy, D. D. Targeted disruption of rc3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus Journal of Neuroscience 2002 22:5525-5535 PMID:12097504
- Sutcliffe, J. G., de Lecea, L. The hypocretins: Setting the arousal threshold Nature Reviews Neuroscience 2002 3:339-349 DOI:10.1038/nrn808 PMID:11988773
- de Lecea, L., Sutcliffe, J. G., Fabre, V. Hypocretins/orexins as integrators of physiological information: Lessons from mutant animals Neuropeptides 2002 36:85-95 DOI:10.1054/npep.2002.0892 PMID:12359500
- Martin, G., Fabre, W., Siggins, G. R., de Lecea, L. Interaction of the hypocretins with neurotransmitters in the nucleus accumbens Regulatory Peptides 2002 104:111-117 DOI:10.1016/s0167-0115(01)00354-8 PMID:11830285
- Bourgin, P., Huitron-Resendiz, S., Spier, A. D., Fabre, V., Morte, B., Criado, J. R., Sutcliffe, J. G., Henriksen, S. J., de Lecea, L. Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons Journal of Neuroscience 2000 20:7760-7765 PMID:11027239
- Sutcliffe, J. G., de Lecea, L. The hypocretins: Excitatory neuromodulatory peptides for multiple homeostatic systems, including sleep and feeding Journal of Neuroscience Research 2000 62:161-168 DOI:10.1002/1097-4547(20001015)62:2<161::aid-jnr1>3.0.co;2-1 PMID:11020209
- de Lecea, L., Sutcliffe, J. G. The hypocretins/orexins: Novel hypothalamic neuropeptides involved in different physiological systems Cellular and Molecular Life Sciences 1999 56:473-480 DOI:10.1007/s000180050446 PMID:11212299
- Calbet, M., Guadano-Ferraz, A., Spier, A. D., Maj, M., Sutcliffe, J. G., Przewlocki, R., de Lecea, L. Cortistatin and somatostatin mrnas are differentially regulated in response to kainate Molecular Brain Research 1999 72:55-64 DOI:10.1016/s0169-328x(99)00220-x PMID:10521599
- Hakansson, M. L., de Lecea, L., Sutcliffe, J. G., Yanagisawa, M., Meister, B. Leptin receptor- and stat3-immunoreactivities in hypocretin/orexin neurones of the lateral hypothalamus Journal of Neuroendocrinology 1999 11:653-663 PMID:10447804
- Criado, J. R., Li, H. T., Jiang, X. H., Spina, M., Huitron-Resendiz, S., Liapakis, G., Calbet, M., Siehler, S., Henriksen, S. J., Koob, G., Hoyer, D., Sutcliffe, J. G., et al. Structural and compositional determinants of cortistatin activity Journal of Neuroscience Research 1999 56:611-619 DOI:10.1002/(sici)1097-4547(19990615)56:6<611::aid-jnr7>3.0.co;2-g PMID:10374816
- Peyron, C., Tighe, D. K., van den Pol, A. N., de Lecea, L., Heller, H. C., Sutcliffe, J. G., Kilduff, T. S. Neurons containing hypocretin (orexin) project to multiple neuronal systems Journal of Neuroscience 1998 18:9996-10015 PMID:9822755
- de Lecea, L., Criado, J. R., Rivera, S., Wen, W., Soriano, E., Henriksen, S. J., Taylor, S. S., Gall, C. M., Sutcliffe, J. G. Endogenous protein kinase a inhibitor (pki alpha) modulates synaptic activity Journal of Neuroscience Research 1998 53:269-278 DOI:10.1002/(sici)1097-4547(19980801)53:3<269::aid-jnr1>3.0.co;2-8 PMID:9698155