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Transcription factor mef2c influences neural stem/progenitor cell differentiation and maturation in vivo

Academic Article
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Overview

authors

  • Li, H.
  • Radford, J. C.
  • Ragusa, M. J.
  • Shea, K. L.
  • McKercher, S. R.
  • Zaremba, J. D.
  • Soussou, W.
  • Nie, Z.
  • Nakanishi, N.
  • Okamoto, S. I.
  • Roberts, Amanda
  • Schwarz, J. J.
  • Lipton, Stuart
  • Kang, Y. J.

publication date

  • 2008

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Emerging evidence suggests that myocyte enhancer factor 2 (MEF2) transcription factors act as effectors of neurogenesis in the brain, with MEF2C the predominant isoform in developing cerebrocortex. Here, we show that conditional knockout of Mef2c in nestin-expressing neural stem/progenitor cells (NSCs) impaired neuronal differentiation in vivo, resulting in aberrant compaction and smaller somal size. NSC proliferation and survival were not affected. Conditional null mice surviving to adulthood manifested more immature electrophysiological network properties and severe behavioral deficits reminiscent of Rett syndrome, an autism-related disorder. Our data support a crucial role for MEF2C in programming early neuronal differentiation and proper distribution within the layers of the neocortex.

subject areas

  • Animals
  • Animals, Newborn
  • Behavior
  • Cell Differentiation
  • Cognition
  • Electrophysiology
  • Embryonic Development
  • MEF2 Transcription Factors
  • Mice
  • Mice, Knockout
  • Mitosis
  • Myogenic Regulatory Factors
  • Neocortex
  • Neurons
  • Phenotype
  • Stem Cells
  • Transcription Factors
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Research

keywords

  • Rett syndrome
  • autism
  • neurogenesis
  • synaptogenesis
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Identity

PubMed Central ID

  • PMC2453715

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.0802876105

PubMed ID

  • 18599437
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Additional Document Info

start page

  • 9397

end page

  • 9402

volume

  • 105

issue

  • 27

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