related to degree

• Seiple, Ian, Ph.D. in Chemistry, Scripps Research 2006 - 2011

authors

• Kock, M.
• Grube, A.
• Seiple, Ian
• Baran, Phil

publication date

• 2007

journal

• Angewandte Chemie-International Edition  Journal

abstract

• Since its discovery in 1993, the marine natural product palau'amine has intrigued natural product chemists. Its exotic molecular architecture and purported bioactivity made it an ideal target for synthesis. However, as the years went by and related marine alkaloids were isolated, a skeptical eye was cast on the structure of palau'amine; recently these suspicions were confirmed and the structure of palau'amine revised. This Minireview gives a careful overview of the structural revision and its ramifications to both its biogenesis and total synthesis.

subject areas

• Alkaloids
• Biological Products
• Guanidines
• Imidazoles
• Magnetic Resonance Spectroscopy
• Models, Molecular
• Molecular Conformation
• Pyrroles
• Spiro Compounds

keywords

• Palau'amine
• natural products
• structure elucidation
• total synthesis

International Standard Serial Number (ISSN)

• 1433-7851

Digital Object Identifier (DOI)

• 10.1002/anie.200701798

PubMed ID

• 17724780

start page

• 6586

end page

• 6594

volume

• 46

issue

• 35