Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Discovery of a small molecule insulin mimetic with antidiabetic activity in mice

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Zhang, B.
  • Salituro, G.
  • Szalkowski, D.
  • Li, Z. H.
  • Zhang, Y.
  • Royo, I.
  • Vilella, D.
  • Diez, M. T.
  • Pelaez, F.
  • Ruby, C.
  • Kendall, R. L.
  • Mao, X. Z.
  • Griffin, Patrick
  • Calaycay, J.
  • Zierath, J. R.
  • Heck, J. V.
  • Smith, Roy
  • Moller, D. E.

publication date

  • May 1999

journal

  • Science  Journal

abstract

  • Insulin elicits a spectrum of biological responses by binding to its cell surface receptor. In a screen for small molecules that activate the human insulin receptor tyrosine kinase, a nonpeptidyl fungal metabolite (L-783,281) was identified that acted as an insulin mimetic in several biochemical and cellular assays. The compound was selective for insulin receptor versus insulin-like growth factor I (IGFI) receptor and other receptor tyrosine kinases. Oral administration of L-783,281 to two mouse models of diabetes resulted in significant lowering in blood glucose levels. These results demonstrate the feasibility of discovering novel insulin receptor activators that may lead to new therapies for diabetes.

subject areas

  • Adenosine Triphosphate
  • Animals
  • Ascomycota
  • Binding Sites
  • Blood Glucose
  • CHO Cells
  • Cricetinae
  • Diabetes Mellitus, Type 2
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Enzyme Activation
  • Glucose Tolerance Test
  • Hyperglycemia
  • Hypoglycemic Agents
  • Indoles
  • Insulin
  • Insulin Receptor Substrate Proteins
  • Mice
  • Mice, Mutant Strains
  • Mice, Obese
  • Molecular Mimicry
  • Phosphoproteins
  • Phosphorylation
  • Protein Conformation
  • Receptor, Epidermal Growth Factor
  • Receptor, IGF Type 1
  • Receptor, Insulin
  • Signal Transduction
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.284.5416.974

PubMed ID

  • 10320380
scroll to property group menus

Additional Document Info

start page

  • 974

end page

  • 977

volume

  • 284

issue

  • 5416

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support