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The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis

Academic Article
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Overview

authors

  • Russell, Paul
  • Nurse, P.

publication date

  • May 1987

journal

  • Cell  Journal

abstract

  • The newly discovered fission yeast mitotic control element nim1+ (new inducer of mitosis) is the first dose-dependent mitotic inducer identified as a protein kinase homolog. Increased nim1+ expression rescues mutants lacking the mitotic inducer cdc25+ and advances cells into mitosis at a reduced cell size; loss of nim1+ delays mitosis until cells have grown to a larger size. The nim1+ gene potentially encodes a 50 kd protein that contains the consensus sequences of protein kinases. Genetic evidence indicates that nim1+ is a negative regulator of the wee1+ mitotic inhibitor, another protein kinase homolog. The combined mitotic induction activities of nim1+ and cdc25+ counteract the wee1+ mitotic inhibitor in a regulatory network that appears also to involve the cdc2+ protein kinase, which is required for mitosis.

subject areas

  • Alleles
  • Amino Acid Sequence
  • Base Sequence
  • Genes
  • Genes, Fungal
  • Genes, Regulator
  • Genotype
  • Mitosis
  • Mutation
  • Protein Kinases
  • Saccharomycetales
  • Schizosaccharomyces
  • Sequence Homology, Nucleic Acid
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(87)90459-4

PubMed ID

  • 3453113
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Additional Document Info

start page

  • 569

end page

  • 576

volume

  • 49

issue

  • 4

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