Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Russell, Paul
  • Nurse, P.

publication date

  • May 1987

journal

  • Cell  Journal

abstract

  • The newly discovered fission yeast mitotic control element nim1+ (new inducer of mitosis) is the first dose-dependent mitotic inducer identified as a protein kinase homolog. Increased nim1+ expression rescues mutants lacking the mitotic inducer cdc25+ and advances cells into mitosis at a reduced cell size; loss of nim1+ delays mitosis until cells have grown to a larger size. The nim1+ gene potentially encodes a 50 kd protein that contains the consensus sequences of protein kinases. Genetic evidence indicates that nim1+ is a negative regulator of the wee1+ mitotic inhibitor, another protein kinase homolog. The combined mitotic induction activities of nim1+ and cdc25+ counteract the wee1+ mitotic inhibitor in a regulatory network that appears also to involve the cdc2+ protein kinase, which is required for mitosis.

subject areas

  • Alleles
  • Amino Acid Sequence
  • Base Sequence
  • Genes
  • Genes, Fungal
  • Genes, Regulator
  • Genotype
  • Mitosis
  • Mutation
  • Protein Kinases
  • Saccharomycetales
  • Schizosaccharomyces
  • Sequence Homology, Nucleic Acid
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(87)90459-4

PubMed ID

  • 3453113
scroll to property group menus

Additional Document Info

start page

  • 569

end page

  • 576

volume

  • 49

issue

  • 4

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support