Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Searching for new reactivity (Nobel lecture)

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Sharpless, K. Barry

publication date

  • 2002

journal

  • Angewandte Chemie-International Edition  Journal

abstract

  • The processes for the selective oxidation of olefins have long been among the most useful tools for day-to-day organic synthesis. Herein, the focus is on the asymmetric-epoxidation (AE) and asymmetric-dihydroxylation (AD) reactions developed by Sharpless and co-workers. The reactions have a wide scope, are simple to run, and involve readily available starting materials. Ligand-accelerated catalysis is crucial to these reactions and might be the agent for uncovering more catalytic processes. In addition to the selectivity benefits of catalysis, the phenomenon of turnover (amplification) raises its potential impact. The author and his co-workers developed small, highly enantioselective catalysts that were unfettered by the "lock-and-key" selectivity of Natures enzymes, and tolerant of substrates throughout the entire range of olefin substitution patterns.

subject areas

  • Catalysis
  • Chemistry
  • History, 20th Century
  • History, 21st Century
  • Nobel Prize
  • Oxidation-Reduction
  • Stereoisomerism
scroll to property group menus

Research

keywords

  • N ligands
  • Nobel lecture
  • asymmetric catalysis
  • epoxidation
  • hydroxylation
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1433-7851

Digital Object Identifier (DOI)

  • 10.1002/1521-3773(20020617)41:12<2024::aid-anie2024>3.0.co;2-o

PubMed ID

  • 19746596
scroll to property group menus

Additional Document Info

start page

  • 2024

end page

  • 2032

volume

  • 41

issue

  • 12

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support