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The most common Chinese rhesus macaque MHC class I molecule shares peptide binding repertoire with the HLA-B7 supertype

Academic Article
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Overview

authors

  • Solomon, C.
  • Southwood, S.
  • Hoof, I.
  • Rudersdorf, R.
  • Peters, B.
  • Sidney, J.
  • Pinilla, C.
  • Marcondes, Maria Cecilia
  • Ling, B. H.
  • Marx, P.
  • Sette, Alessandro
  • Mothe, B. R.

publication date

  • July 2010

journal

  • Immunogenetics  Journal

abstract

  • Of the two rhesus macaque subspecies used for AIDS studies, the Simian immunodeficiency virus-infected Indian rhesus macaque (Macaca mulatta) is the most established model of HIV infection, providing both insight into pathogenesis and a system for testing novel vaccines. Despite the Chinese rhesus macaque potentially being a more relevant model for AIDS outcomes than the Indian rhesus macaque, the Chinese-origin rhesus macaques have not been well-characterized for their major histocompatibility complex (MHC) composition and function, reducing their greater utilization. In this study, we characterized a total of 50 unique Chinese rhesus macaques from several varying origins for their entire MHC class I allele composition and identified a total of 58 unique complete MHC class I sequences. Only nine of the sequences had been associated with Indian rhesus macaques, and 28/58 (48.3%) of the sequences identified were novel. From all MHC alleles detected, we prioritized Mamu-A1*02201 for functional characterization based on its higher frequency of expression. Upon the development of MHC/peptide binding assays and definition of its associated motif, we revealed that this allele shares peptide binding characteristics with the HLA-B7 supertype, the most frequent supertype in human populations. These studies provide the first functional characterization of an MHC class I molecule in the context of Chinese rhesus macaques and the first instance of HLA-B7 analogy for rhesus macaques.

subject areas

  • Animals
  • China
  • Genes, MHC Class I
  • Histocompatibility Antigens Class I
  • Humans
  • India
  • Macaca mulatta
  • Peptide Fragments
  • Phylogeny
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
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Research

keywords

  • CTL
  • HLA
  • MHC
  • Rhesus macaque
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Identity

PubMed Central ID

  • PMC2890073

International Standard Serial Number (ISSN)

  • 0093-7711

Digital Object Identifier (DOI)

  • 10.1007/s00251-010-0450-3

PubMed ID

  • 20480161
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Additional Document Info

start page

  • 451

end page

  • 464

volume

  • 62

issue

  • 7

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