Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Pharmacology of nuclear receptor-coregulator recognition

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Savkur, R. S.
  • Bramlett, K. S.
  • Clawson, D.
  • Burris, Thomas

publication date

  • 2004

journal

  • Nuclear Receptor Coregulators  Journal

abstract

  • The nuclear receptor (NR) superfamily comprises approximately 50 members that are responsible for regulating a number of physiologic processes in humans, including metabolism, homeostasis, and reproduction. Included in the superfamily are the receptors for steroids, lipophilic vitamins, bile acids, retinoids, and various fatty acids. NRs exert their action as transcription factors that directly bind to the promoters of target genes and regulate their rate of transcription. To modulate transcription, however, NRs must recruit a number of accessory coregulators known as corepressors and coactivators. These coregulators harbor a variety of activities, such as the ability to modify chromatin structure, interact with basal transcriptional machinery, and modify RNA splicing. Recent studies have revealed that the pharmacological characteristics of various NR ligands are regulated by their ability to modulate the coregulator interaction profile of an NR.

subject areas

  • Animals
  • Carrier Proteins
  • Chromatin
  • Gene Expression Regulation
  • Humans
  • Intracellular Signaling Peptides and Proteins
  • Ligands
  • Mediator Complex Subunit 1
  • Membrane Proteins
  • Methyltransferases
  • Nuclear Proteins
  • Protein-Arginine N-Methyltransferases
  • RNA, Long Noncoding
  • RNA, Untranslated
  • Receptors, Cytoplasmic and Nuclear
  • Receptors, Steroid
  • Repressor Proteins
  • Thyroid Hormones
  • Trans-Activators
  • Transcription Factors
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0083-6729

PubMed ID

  • 15193454
scroll to property group menus

Additional Document Info

start page

  • 145

end page

  • 183

volume

  • 68

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support