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Synthesis and evaluation of morpholino- and pyrrolidinosphingolipids as inhibitors of glucosylceramide synthase

Academic Article
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Overview

authors

  • Miura, T.
  • Kajimoto, T.
  • Jimbo, M.
  • Yamagishi, K.
  • Inokuchi, J. C.
  • Wong, Chi-Huey

publication date

  • September 1998

journal

  • Bioorganic & Medicinal Chemistry  Journal

abstract

  • This paper describes the new synthesis and evaluation of some morpholino- and pyrrolidinosphingolipids and mimics as inhibitors of glucosylceramide synthase. It was found that the pyrrolidino derivatives are generally more active than the morpholino derivatives and the best one was shown to be a nanomolar inhibitor.

subject areas

  • Drug Evaluation
  • Enzyme Inhibitors
  • Glucosyltransferases
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Morpholines
  • Pyrrolidines
  • Spectrometry, Mass, Fast Atom Bombardment
  • Sphingolipids
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Identity

International Standard Serial Number (ISSN)

  • 0968-0896

Digital Object Identifier (DOI)

  • 10.1016/s0968-0896(98)00077-7

PubMed ID

  • 9801819
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Additional Document Info

start page

  • 1481

end page

  • 1489

volume

  • 6

issue

  • 9

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