Synthesis and sar of piperazine amides as novel c-jun N-terminal kinase (JNK) inhibitors

Academic Article
uri icon

publication date

  • 2009

abstract

  • A novel series of c-jun N-terminal kinase (JNK) inhibitors were designed and developed from a high-throughput-screening hit. Through the optimization of the piperazine amide 1, several potent compounds were discovered. The X-ray crystal structure of 4g showed a unique binding mode different from other well known JNK3 inhibitors.