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Clinical and autoantibody correlations in Orientals with systemic lupus erythematosus

Academic Article
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Overview

authors

  • Boey, M. L.
  • Peebles, C. L.
  • Tsay, G.
  • Feng, P. H.
  • Tan, Eng

publication date

  • November 1988

journal

  • Annals of the Rheumatic Diseases  Journal

abstract

  • Serum samples from 94 patients with systemic lupus erythematosus (SLE) from a medical unit in Singapore were analysed for autoantibodies of 10 different specificities. The prevalence of antibodies to the following antigens was as follows: double stranded (ds) DNA (43%), histone (81%), Sm (26%), nuclear ribonuclear protein (nRNP) (32%), SS-A(Ro) (63%), SS-B(La) (12%), SL/Ki (9%), ribosomal RNP (rRNP) (16%), p70/p80 (5%), proliferating cell nuclear antigen (PCNA) (3%). Except for a higher prevalence of anti-SS-A(Ro), other autoantibodies were within the range reported from Western countries, indicating a high uniformity of autoantibody profiles in SLE in different countries. Patients with neuropsychiatric manifestations showed a higher plurality of antibodies per patient than patients without neuropsychiatric symptoms, 4.22 v 2.77. Patients with anti-Sm were more likely to have active lupus disease. There was no increased prevalence or specific type of autoantibody in those with renal manifestations.

subject areas

  • Adolescent
  • Adult
  • Antibodies, Antinuclear
  • Autoantigens
  • Central Nervous System Diseases
  • China
  • DNA
  • Female
  • Histones
  • Humans
  • India
  • Lupus Erythematosus, Systemic
  • Male
  • Middle Aged
  • RNA, Small Cytoplasmic
  • Ribonucleoproteins
  • Ribonucleoproteins, Small Nuclear
  • Singapore
  • snRNP Core Proteins
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Identity

PubMed Central ID

  • PMC1003633

International Standard Serial Number (ISSN)

  • 0003-4967

Digital Object Identifier (DOI)

  • 10.1136/ard.47.11.918

PubMed ID

  • 3264694
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Additional Document Info

start page

  • 918

end page

  • 923

volume

  • 47

issue

  • 11

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