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Potent inhibition of hiv-1 entry with a chemically programmed antibody aided by an efficient organocatalytic synthesis

Academic Article
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Overview

authors

  • Gavrilyuk, J.
  • Uehara, H.
  • Otsubo, N.
  • Hessell, A.
  • Burton, Dennis
  • Barbas III, Carlos

publication date

  • October 2010

journal

  • ChemBioChem  Journal

subject areas

  • Antibodies, Catalytic
  • Benzoates
  • CCR5 Receptor Antagonists
  • Catalysis
  • Cell Line
  • Fluorescent Dyes
  • Fructose-Bisphosphate Aldolase
  • HIV Envelope Protein gp120
  • HIV Fusion Inhibitors
  • HIV-1
  • Humans
  • Immunoglobulin Fab Fragments
  • Piperazines
  • Proline
  • Protein Binding
  • Receptors, CCR5
  • Rhodamines
  • Simian Immunodeficiency Virus
  • Spiro Compounds
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Research

keywords

  • CCR5 inhibition
  • anti-HIV antibody
  • asymmetric synthesis
  • neutralizing antibody
  • organocatalysis
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Identity

International Standard Serial Number (ISSN)

  • 1439-4227

Digital Object Identifier (DOI)

  • 10.1002/cbic.201000432

PubMed ID

  • 20845359
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Additional Document Info

start page

  • 2113

end page

  • 2118

volume

  • 11

issue

  • 15

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