Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

A functional interaction between RIP140 and PGC-1 alpha regulates the expression of the lipid droplet protein CIDEA

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Hallberg, M.
  • Morganstein, D. L.
  • Kiskinis, E.
  • Shah, K.
  • Kralli, Anastasia
  • Dilworth, S. M.
  • White, R.
  • Parker, M. G.
  • Christian, M.

publication date

  • November 2008

journal

  • Molecular and Cellular Biology  Journal

abstract

  • Nuclear receptors activate or repress target genes depending on the recruitment of coactivators or corepressors. The corepressor RIP140 and the PPAR coactivator 1alpha (PGC-1alpha) both play key roles in the regulated transcription of genes involved in energy homeostasis. We investigated the roles of RIP140 and PGC-1alpha in controlling the expression of CIDEA, an important regulatory factor in adipose cell function and obesity. Ectopically expressed CIDEA surrounded lipid droplets in brown adipocytes and induced the formation of lipid droplets in nonadipogenic cell lines. The expression and promoter activity of CIDEA was repressed by RIP140 and induced by PGC-1alpha, mediated through the binding of estrogen-related receptor alpha and NRF-1 to their cognate binding sites. Importantly, we demonstrate that RIP140 interacts directly with PGC-1alpha and suppresses its activity. The direct antagonism of PGC-1alpha by RIP140 provides a mechanism for regulating target gene transcription via nuclear receptor-dependent and -independent pathways.

subject areas

  • Adaptor Proteins, Signal Transducing
  • Adipocytes, Brown
  • Animals
  • Apoptosis Regulatory Proteins
  • Base Sequence
  • Cell Line
  • Gene Expression Regulation
  • Humans
  • Lipids
  • Mice
  • Mice, Knockout
  • Nuclear Proteins
  • Promoter Regions, Genetic
  • Recombinant Fusion Proteins
  • Trans-Activators
  • Transcription Factors
scroll to property group menus

Identity

PubMed Central ID

  • PMC2573308

International Standard Serial Number (ISSN)

  • 0270-7306

Digital Object Identifier (DOI)

  • 10.1128/mcb.00504-08

PubMed ID

  • 18794372
scroll to property group menus

Additional Document Info

start page

  • 6785

end page

  • 6795

volume

  • 28

issue

  • 22

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support