Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

An unexpected switch in the modulation of AI-2-based quorum sensing discovered through synthetic 4,5-dihydroxy-2,3-pentanedione analogues

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Lowery, Colin, Ph.D. in Chemistry, Scripps Research 2004 - 2010

authors

  • Lowery, Colin
  • Park, J.
  • Kaufmann, Gunnar
  • Janda, Kim

publication date

  • July 2008

journal

  • Journal of the American Chemical Society  Journal

abstract

  • Quorum sensing (QS) has traditionally referred to a mechanism of communication within a species of bacteria. However, emerging research implicates QS in interspecies communication and competition, and such systems have been proposed in a wide variety of bacteria. The AI-2-based QS system represents the most studied of these proposed interspecies systems, and has been proposed to regulate diverse functions such as bioluminescence, expression of virulence factors, and biofilm formation. As such, the development of modulatory compounds, both agonists and antagonists, is of great interest for the treatment of bacterial infections and the study of unknown AI-2-based QS systems. Toward this end, we have designed and synthesized a panel of 4,5-dihydroxy-2,3-pentanedione/AI-2 analogues and evaluated their effects on the AI-2 QS of various bacteria. The panel of compounds exhibited differential effects in the bacterial cell lines examined, providing a platform for the development of broad-spectrum modulators of AI-2-based QS.

subject areas

  • Enzyme Induction
  • Homoserine
  • Lactones
  • Luminescent Measurements
  • Pentanones
  • Quorum Sensing
  • Salmonella typhimurium
  • Vibrio
  • beta-Galactosidase
scroll to property group menus

Identity

PubMed Central ID

  • PMC2668569

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja802353j

PubMed ID

  • 18576653
scroll to property group menus

Additional Document Info

start page

  • 9200

end page

  • 9201

volume

  • 130

issue

  • 29

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support