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Signaling t-cell survival and death by il-2 and il-15

Academic Article
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Overview

authors

  • Zambricki, E.
  • Shigeoka, A.
  • Kishimoto, H.
  • Sprent, Jonathan
  • Burakoff, S.
  • Carpenter, C.
  • Milford, E.
  • McKay, Dianne

publication date

  • November 2005

journal

  • American Journal of Transplantation  Journal

abstract

  • Interleukin 2 (IL-2) and interleukin 15 (IL-15) bind to common T-cell surface receptors comprised of unique alpha (IL-2R alpha or IL-15R alpha) and shared beta/gamma chain subunits. Ligation of this receptor by IL-2 can lead to apoptosis whereas IL-15 ligation favors cell survival. Our study examined intra-cellular signaling events associated with IL-2- and IL-15-induced apoptosis and survival in human T cells. We found IL-2 and IL-15 could both induce apoptosis and survival; the outcome depended on cytokine concentration. No qualitative differences in Jak/Stat, Ras/MAPK or PI3K/AKT signaling were seen over a wide range of IL-2 and IL-15 concentrations. These findings suggest that, like T-cell receptor signaling, IL-2R beta/gamma chain signaling is regulated, or "tuned," by the concentration of cytokine.

subject areas

  • Apoptosis
  • Cell Death
  • Cell Line
  • Cell Survival
  • Humans
  • Interleukin-15
  • Interleukin-2
  • Lymphocyte Activation
  • Receptors, Interleukin-2
  • Signal Transduction
  • T-Lymphocytes
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Research

keywords

  • T cells
  • cytokine receptors
  • cytokines
  • signal transduction
  • transplantation
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Identity

International Standard Serial Number (ISSN)

  • 1600-6135

Digital Object Identifier (DOI)

  • 10.1111/j.1600-6143.2005.01075.x

PubMed ID

  • 16212621
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Additional Document Info

start page

  • 2623

end page

  • 2631

volume

  • 5

issue

  • 11

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