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Antiviral cd4(+) memory t cells are il-15 dependent

Academic Article
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Overview

authors

  • Purton, J. F.
  • Tan, J. T.
  • Rubinstein, M. P.
  • Kim, Dae Hee
  • Sprent, Jonathan
  • Surh, Charles

publication date

  • April 2007

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Survival and intermittent proliferation of memory CD4(+) and CD8(+) T cells appear to be controlled by different homeostatic mechanisms. In particular, contact with interleukin (IL)-15 has a decisive influence on memory CD8(+) cells, but not memory CD4(+) cells. Past studies of memory CD4(+) cells have relied heavily on the use of naturally occurring memory phenotype (MP) cells as a surrogate for antigen (Ag)-specific memory cells. However, we show here that MP CD4(+) cells contain a prominent subset of rapidly proliferating major histocompatibility complex (MHC) II-dependent cells. In contrast, Ag-specific memory CD4 cells have a slow turnover rate and are MHC II independent. In irradiated hosts, these latter cells ignore IL-15 and expand in response to the elevated levels of IL-7 in the lymphopenic hosts. In contrast, in normal nonlymphopenic hosts where IL-7 levels are low, memory CD4 cells are heavily dependent on IL-15. Significantly, memory CD4(+) responsiveness to endogenous IL-15 reflects marked competition from other cells, especially CD8(+) and natural killer cells, and increases considerably after removal of these cells. Therefore, under normal physiological conditions, homeostasis of CD8(+) and CD4(+) memory cells is quite similar and involves IL-15 and IL-7.

subject areas

  • Animals
  • Antigens
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Differentiation
  • Cell Proliferation
  • Cells, Cultured
  • Homeostasis
  • Immunologic Memory
  • Interleukin-15
  • Interleukin-7
  • Killer Cells, Natural
  • Lymphocytic choriomeningitis virus
  • Mice
  • Phenotype
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Identity

PubMed Central ID

  • PMC2118539

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20061805

PubMed ID

  • 17420265
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Additional Document Info

start page

  • 951

end page

  • 961

volume

  • 204

issue

  • 4

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