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Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin A's zinc endopeptidase

Academic Article
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Overview

authors

  • Barbieri, J. T.
  • Pellett, S.
  • Capkova, K.
  • Hixon, M. S.
  • Janda, Kim
  • Johnson, E. A.

publication date

  • January 2010

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

subject areas

  • Benzylidene Compounds
  • Botulinum Toxins, Type A
  • Catalytic Domain
  • Cyclopentanes
  • Metalloendopeptidases
  • Protease Inhibitors
  • Zinc
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Research

keywords

  • Botulinum neurotoxin
  • Irreversible inhibition
  • Protease inhibitor
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Identity

PubMed Central ID

  • PMC2818383

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2009.10.129

PubMed ID

  • 19914829
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Additional Document Info

start page

  • 206

end page

  • 208

volume

  • 20

issue

  • 1

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