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Functional, molecular and pharmacological advances in 5-ht7 receptor research

Academic Article
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Overview

authors

  • Hedlund, Peter
  • Sutcliffe, J. Gregor

publication date

  • September 2004

journal

  • Trends in Pharmacological Sciences  Journal

abstract

  • The 5-HT7 receptor was among a group of 5-HT receptors that were discovered using targeted cloning strategies 12 years ago. This receptor is a seven-transmembrane-domain G-protein-coupled receptor that is positively linked to adenylyl cyclase. The distributions of 5-HT7 receptor mRNA, immunolabeling and radioligand binding exhibit strong similarities, with the highest receptor densities present in the thalamus and hypothalamus and significant densities present in the hippocampus and cortex. The recent availability of selective antagonists and knockout mice strains has dramatically increased our knowledge about this receptor. Together with unselective agonists, these new tools have helped to reveal the 5-HT7 receptor distribution in more detail. Important functional roles for the 5-HT7 receptor in thermoregulation, circadian rhythm, learning and memory, hippocampal signaling and sleep have also been established. Hypotheses driving current research indicate that this receptor might be involved in mood regulation, suggesting that the 5-HT7 receptor is a putative target in the treatment of depression.

subject areas

  • Affect
  • Animals
  • Body Temperature Regulation
  • Circadian Rhythm
  • Endocrine System
  • Hippocampus
  • Learning
  • Mice
  • Mice, Knockout
  • Receptors, Serotonin
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Signal Transduction
  • Sleep
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Identity

International Standard Serial Number (ISSN)

  • 0165-6147

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2004.07.002

PubMed ID

  • 15559250
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Additional Document Info

start page

  • 481

end page

  • 486

volume

  • 25

issue

  • 9

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