Differences in one-way active-avoidance learning in mice of 3 inbred strains

Academic Article

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Overview

authors

• Weinberger, S. B.
• Koob, George
• Martinez, J. L.

publication date

• March 1992

journal

• Behavior Genetics  Journal

abstract

• DBA/2J, C57BL/6J, and C3H/HeJ mice were given 10 one-way avoidance training trials per day, using an unconditioned stimulus intensity that provided equivalent motivation for learning to mice of all three strains, and were found to differ in their abilities to learn and retain the response. DBA/2J mice acquired the response in fewer days than did the mice of the other two strains, although C57BL/6J mice eventually reached a level of performance similar to that of DBA/2J mice. Both the rate of acquisition and the level at which avoidance performance stabilized were significantly lower in C3H/HeJ, than in DBA/2J or C57BL/6J, mice. In addition, DBA/2J mice showed a significantly greater task retention from one testing day to the next than did C57BL/6J or C3H/HeJ mice.

subject areas

• Animals
• Avoidance Learning
• Electroshock
• Genotype
• Male
• Mental Recall
• Mice
• Mice, Inbred Strains
• Retention (Psychology)
• Sensory Thresholds
• Species Specificity

Research

keywords

• C3H/HEJ
• C57BL/6J
• DBA/2J
• FOOTSHOCK SENSITIVITY
• INBRED MICE
• ONE-WAY ACTIVE AVOIDANCE

Identity

International Standard Serial Number (ISSN)

• 0001-8244

Digital Object Identifier (DOI)

• 10.1007/bf01066996

PubMed ID

• 1596257

Additional Document Info

start page

• 177

end page

• 188

volume

• 22

issue

• 2