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Scientific and therapeutic advances in antiplatelet therapy

Academic Article
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Overview

authors

  • Bhatt, D. L.
  • Topol, Eric

publication date

  • January 2003

journal

  • Nature Reviews Drug Discovery  Journal

abstract

  • Over the past decade, the platelet has emerged as a pivotal entity in cardiovascular diseases. Indeed, the 'preeminence of the platelet' has spawned a variety of drugs that have been shown in large-scale randomized trials to improve patient outcomes in acute coronary syndromes and percutaneous revascularization procedures. Although the platelet was initially viewed only as a bystander in haemostasis, it is now evident that the platelet is in fact a key mediator of thrombosis as well as of inflammation. New insights at the cellular and genomic levels will probably generate novel drugs to inhibit platelet function more effectively and safely than previously possible.

subject areas

  • Adenosine Diphosphate
  • Animals
  • Aspirin
  • Blood Platelets
  • Cardiovascular Diseases
  • Humans
  • Platelet Aggregation Inhibitors
  • Platelet Glycoprotein GPIIb-IIIa Complex
  • Polymorphism, Single Nucleotide
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Identity

International Standard Serial Number (ISSN)

  • 1474-1776

Digital Object Identifier (DOI)

  • 10.1038/nrd985

PubMed ID

  • 12509756
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Additional Document Info

start page

  • 15

end page

  • 28

volume

  • 2

issue

  • 1

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