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Allelic exclusion of mouse t-cell receptor-alpha chains occurs at the time of thymocyte tcr up-regulation

Academic Article
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Overview

authors

  • Alam, S. M.
  • Crispe, I. N.
  • Gascoigne, Nicholas

publication date

  • October 1995

journal

  • Immunity  Journal

abstract

  • We report a detailed analysis of TCR V alpha and V beta chain expression on immature versus mature thymocytes of normal, TCR beta-transgenic, and TCR alpha-hemizygous mice. Chain pairing between TCR V alpha and V beta chains is random on immature thymocytes, but individual chain pairs are selected in mature thymocytes. This indicates that V alpha-V beta chain pairing preferences are determined during thymic selection, and not as a result of structural constraints. Dual V alpha chain expression is found frequently on immature, but not mature thymocytes. It is not found in TCR alpha-hemizygous mice, showing that cell surface expression of dual alpha chains is caused by lack of allelic exclusion in immature thymocytes. Down-regulation of one of the alpha chains occurs concurrently with differentiation from TCRlo, CD69- to TCRhi, CD69+ phenotype, suggesting that it is associated with positive selection of the functional TCR.

subject areas

  • Alleles
  • Animals
  • Antigens, CD
  • Cell Differentiation
  • Mice
  • Mice, Inbred C57BL
  • Mice, Transgenic
  • Receptors, Antigen, T-Cell, alpha-beta
  • T-Lymphocytes
  • Thymus Gland
  • Up-Regulation
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Identity

International Standard Serial Number (ISSN)

  • 1074-7613

PubMed ID

  • 7584136
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Additional Document Info

start page

  • 449

end page

  • 458

volume

  • 3

issue

  • 4

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