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Glycylprolyl-diaminopeptidase in human leukocytes: selective occurrence in T lymphocytes and influence on the total serum enzyme activity

Academic Article
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Overview

authors

  • Kasahara, Y.
  • Lerouxroels, G.
  • Nakamura, R.
  • Chisari, Francis

publication date

  • 1984

journal

  • Clinica Chimica Acta  Journal

abstract

  • Using biochemical methods glycylprolyl-diaminopeptidase (GP-DAP, EC 3.4.14.5) was measured in purified leukocyte subpopulations and found selectively in T lymphocytes. In 129 subjects with normal hepatic function a significant correlation was observed between the serum GP-DAP activity and the peripheral blood lymphocyte count. In four patients suffering from rheumatoid arthritis, four weeks of thoracic duct drainage resulted in a reduction of the peripheral blood lymphocyte count and a concomitant decrease of the serum GP-DAP activity. These observations suggest that lymphocytic GP-DAP may contribute to the total serum GP-DAP activity.

subject areas

  • Arthritis, Rheumatoid
  • Dipeptidyl Peptidase 4
  • Dipeptidyl-Peptidases and Tripeptidyl-Peptidases
  • Drainage
  • Endopeptidases
  • Humans
  • Leukocyte Count
  • T-Lymphocytes
  • Thoracic Duct
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Identity

International Standard Serial Number (ISSN)

  • 0009-8981

Digital Object Identifier (DOI)

  • 10.1016/0009-8981(84)90275-4

PubMed ID

  • 6146412
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Additional Document Info

start page

  • 295

end page

  • 302

volume

  • 139

issue

  • 3

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