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Hairy cell leukemia: Diagnostic pathology

Academic Article
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Overview

authors

  • Sharpe, R. W.
  • Bethel, K. J.

publication date

  • 2006

journal

  • Hematology-Oncology Clinics of North America  Journal

abstract

  • The pathology of HCL has been reviewed with a focus on the diagnostic hematopathology of this rare, but fascinating, disease. The discrimination of HCL from other B-cell lymphoproliferations, particularly HCL-V and SMZL, has been emphasized. The unique responsiveness of HCL to 2-CdA and other chemotherapeutic agents makes this distinction critical. Fortunately, HCL has consistent cytologic, histologic, cytochemical, and immunologic features that make classification reliable and reproducible. Less straightforward is the differential diagnosis of SMZL and HCL-V, problematic because of the rarity of both disorders, lack of discriminating evidence-based criteria, and perhaps a biologic kinship between these two disorders that share many clinical and pathologic features. Fortunately, this is not a clinically critical distinction.

subject areas

  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Bone Marrow
  • Diagnosis, Differential
  • Flow Cytometry
  • Humans
  • Leukemia, Hairy Cell
  • Lymph Nodes
  • Lymphoma, B-Cell
  • Lymphoma, Non-Hodgkin
  • Spleen
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Identity

International Standard Serial Number (ISSN)

  • 0889-8588

Digital Object Identifier (DOI)

  • 10.1016/j.hoc.2006.06.010

PubMed ID

  • 16990105
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Additional Document Info

start page

  • 1023

end page

  • 1049

volume

  • 20

issue

  • 5

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