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A new approach for evaluating antigen-specific t cell responses to myelin antigens during the course of multiple sclerosis

Academic Article
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Overview

authors

  • Arbour, N.
  • Holz, A.
  • Sipe, J. C.
  • Naniche, D.
  • Romine, J. S.
  • Zyroff, J.
  • Oldstone, Michael

publication date

  • 2003

journal

  • Journal of Neuroimmunology  Journal

abstract

  • We used a flow cytometry assay to measure proliferation and cytokine production of self-antigen-specific T cells in individual patients during the clinical course of multiple sclerosis (MS). Myelin-associated oligodendrocytic basic protein (MOBP) was selected for proof of principles in the assay, along with myelin basic protein (MBP) to assess specific activated T cells in 10 MS patients over an 18-month period, in parallel with brain magnetic resonance imaging (MRI) scans and clinical rating scale. A positive correlation occurred between antigen-specific T cell proliferation and interferon-gamma production with clinical relapses and MRI lesion activity that was absent when the same patients were in remission.

subject areas

  • Adult
  • Autoantigens
  • Brain
  • Epitopes, T-Lymphocyte
  • Female
  • Flow Cytometry
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Myelin Basic Protein
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Myelin-Oligodendrocyte Glycoprotein
  • T-Lymphocytes
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Research

keywords

  • T cell
  • autoimmunity
  • central nervous system
  • flow cytometry
  • self-antigen
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Identity

International Standard Serial Number (ISSN)

  • 0165-5728

Digital Object Identifier (DOI)

  • 10.1016/s0165-5728(03)00080-8

PubMed ID

  • 12667664
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Additional Document Info

start page

  • 197

end page

  • 209

volume

  • 137

issue

  • 1-2

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