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The immune-response towards beta-adrenergic ligands and their receptors .6. Idiotypy of monoclonal anti-alprenolol antibodies

Academic Article
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Overview

authors

  • Chamat, S.
  • Hoebeke, J.
  • Emorine, L.
  • Guillet, J. G.
  • Strosberg, Donny

publication date

  • May 1986

journal

  • Journal of Immunology  Journal

abstract

  • Four murine monoclonal antibodies specific for alprenolol, a synthetic beta-adrenergic ligand, with different binding properties towards alprenolol and other beta-adrenergic antagonists and agonists (as described in a previous report) were used to induce anti-idiotypic responses in rabbits and mice. Three of the rabbit anti-idiotypes inhibited, and one increased the binding of tritiated dihydroalprenolol to the Ab1 against which they were induced. The syngeneic mouse anti-idiotypes all had an inhibitory effect on the ligand binding to their corresponding Ab1. Cross-reactivity tests of the xenogeneic and syngeneic anti-idiotypes were positive only for two monoclonal anti-alprenolol antibodies. Cross-reaction could be shown neither on a panel of 15 other monoclonals, nor on polyclonal anti-alprenolol antibodies of the BALB/c and the C57BL/10 mice. These results suggest that the immune response against alprenolol results in antibodies with mostly private idiotypic determinants. Moreover, the properties of the anti-idiotypic response against the same monoclonal antibody seem to be different according to the species used for anti-idiotypic induction.

subject areas

  • Alprenolol
  • Animals
  • Antibodies, Monoclonal
  • Antibody Affinity
  • Cross Reactions
  • Immunoglobulin Idiotypes
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Rabbits
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Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 3701062
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Additional Document Info

start page

  • 3805

end page

  • 3811

volume

  • 136

issue

  • 10

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