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Post-learning ethanol effects on a water-finding task in rats

Academic Article
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Overview

authors

  • Melia, K. F.
  • Ehlers, Cindy
  • Lebrun, C. J.
  • Koob, George

publication date

  • June 1986

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • Ethanol's post-training facilitation of memory was examined using a latent learning paradigm known as the "water-finding task." Rats were assigned to one of two ethanol groups (E0.75 g/kg or E1.5 g/kg) or to a control group (saline) and individually placed in a novel open field containing a drinking tube. Following this exposure, subjects were immediately administered intraperitoneal (IP) injections of either the saline or ethanol and 48 hours later, re-introduced to the field. Initial latencies to contact the tube each time were recorded. A linear regression analysis of trial 2 latencies regressed onto trial 1 latencies indicated a statistically significant effect of ethanol on the relation between initial and subsequent latencies. Though the control rats' trial 2 latencies were completely random with respect to their previous speeds (rSAL = -0.07), the ethanol rats' trial 2 latencies were positively correlated with initial speeds (rE0.75 = 0.35, rE1.5 = 0.67). These results suggest that under conditions of post-training ethanol, trial 2 behavior is more similar to, or controlled by, trial 1 behavior and are consistent with the argument that, under certain training and testing contexts, ethanol can come to exert control over a response's recurrence.

subject areas

  • Analysis of Variance
  • Animals
  • Ethanol
  • Learning
  • Male
  • Memory
  • Rats
  • Rats, Inbred Strains
  • Reaction Time
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/0091-3057(86)90528-9

PubMed ID

  • 3737649
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Additional Document Info

start page

  • 1813

end page

  • 1815

volume

  • 24

issue

  • 6

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