Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

A biometrical genome search in rats reveals the multigenic basis of blood-pressure variation

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Schork, Nicholas
  • Krieger, J. E.
  • Trolliet, M. R.
  • Franchini, K. G.
  • Koike, G.
  • Krieger, E. M.
  • Lander, E. S.
  • Dzau, V. J.
  • Jacob, H. J.

publication date

  • September 1995

journal

  • Genome Research  Journal

abstract

  • A genome-wide search for multiple loci influencing salt-loaded systolic blood pressure (NaSBP) variation among 188 F2 progeny from a cross between the Brown-Norway and spontaneously hypertensive rat strains was pursued in an effort to gain insight into the polygenic basis of blood pressure regulation. The results suggest that loci within five to six genomic regions collectively explain approximately 43% of the total NaSBP variation exhibited among the 188 F2 progeny. Many of these loci are in regions that previous studies have not implicated in blood pressure regulation. Ultimately, however, this study not only sheds light on the multigenic basis of blood pressure but provides further evidence that the identification of the genetic determinants of polygenic traits in mammals is possible with modern biometrical and molecular genetic tools in controlled settings (i.e., breeding paradigm and model organism).

subject areas

  • Animals
  • Biometry
  • Blood Pressure
  • Crosses, Genetic
  • Female
  • Genetic Variation
  • Male
  • Rats
  • Rats, Inbred BN
  • Rats, Inbred SHR
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1054-9803

Digital Object Identifier (DOI)

  • 10.1101/gr.5.2.164

PubMed ID

  • 9132270
scroll to property group menus

Additional Document Info

start page

  • 164

end page

  • 172

volume

  • 5

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support