Diphenylprolinol silyl ether catalysis in an asymmetric formal carbo 3+3 cycloaddition reaction via a domino michael/knoevenagel condensation

Academic Article
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publication date

  • 2009

abstract

  • Diphenylprolinol silyl ether was found to catalyze the formal carbo [3 + 3] cycloaddition reaction through the domino reaction via the Michael reaction, followed by Knoevenagel condensation of the alpha,beta-unsaturated aldehyde and dimethyl 3-oxopentanedioate, affording substituted cyclohexenone derivatives with excellent enantioselectivity.