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Rare antibodies from combinatorial libraries suggests an sos component of the human immunological repertoire

Academic Article
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Overview

authors

  • Lerner, Richard

publication date

  • 2011

journal

  • Molecular Biosystems  Journal

abstract

  • Convergence of observations from different sources is the norm in science. However, when convergence occurs in man for antibodies it is remarkable because the repertoire of possible immunoglobulin products is very large and diverse. Thus, one would not expect to see the same antibody twice from divergent populations unless there is special significance as to why the immune response is constrained. Now, broadly neutralizing antibodies isolated from combinatorial libraries from three separate populations have been shown to all use the same (V(H) 1-69) germ line gene and interact with the influenza virus in very similar ways. Here we discuss the reasons for this convergence in terms of how the immunological repertoire responds to emergency situations where time is short as occurs, for example, in potentially lethal infections. It is suggested that there is a first responder or S.O.S. component of the antibody repertoire that evolved to initiate rapid defense against infectious agents. The discovery of the homologies between these commonly produced antibodies may have significance for the design of novel vaccines. Finally, these convergent results may give much insight into why antibodies encoded by the V(H) 1-69 germ line gene are highly over represented in B-cell lymphomas.

subject areas

  • Animals
  • Antibodies
  • Humans
  • Infection
  • Neoplasms
  • Orthomyxoviridae
  • SOS Response (Genetics)
  • Vaccines
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Identity

International Standard Serial Number (ISSN)

  • 1742-206X

Digital Object Identifier (DOI)

  • 10.1039/c0mb00310g

PubMed ID

  • 21298133
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Additional Document Info

start page

  • 1004

end page

  • 1012

volume

  • 7

issue

  • 4

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