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Corticotropin-releasing factor in the paraventricular nucleus modulates feeding induced by neuropeptide-y

Academic Article
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Overview

authors

  • Heinrichs, S. C.
  • Menzaghi, F.
  • Pich, E. M.
  • Hauger, R. L.
  • Koob, George

publication date

  • May 1993

journal

  • Brain Research  Journal

abstract

  • Central administration of neuropeptide Y (NPY) exerts a potent orexigenic effect in rats, whereas injection of corticotropin-releasing factor (CRF) suppresses food intake. Anatomical evidence of NPY-containing terminals located in close proximity to CRF-containing neurons and terminals of the hypothalamus and amygdala suggests possible interactions of these neuropeptide systems in food-intake regulation. The present study examined the effect of local administration of the CRF antagonist, alpha-helical CRF9-41, or peripheral treatment with dexamethasone on NPY-induced hyperphagia. Injection of a 250-ng dose of alpha-hel CRF within the paraventricular nucleus (PVN) of the hypothalamus significantly potentiated the feeding induced by a 500-ng dose of NPY injected into the same locus. In contrast, feeding induced by administration of the 500-ng dose of NPY into the ventromedial hypothalamus (VMH) was not modified by intra-VMH pre-treatment with a 250-ng dose of CRF antagonist. No effects of NPY or alpha-hel CRF on feeding were observed after administration into the central nucleus of the amygdala. Systemic pre-treatment with the synthetic glucocorticoid dexamethasone at a dose known to downregulate the function of CRF neurons in the PVN (100 micrograms/kg) enhanced feeding induced by intra-PVN administration of a 500-ng dose of NPY. These results suggest that hypothalamic CRF systems in the PVN exert inhibitory control over NPY-induced food intake.

subject areas

  • Animals
  • Appetite Regulation
  • Corticotropin-Releasing Hormone
  • Dexamethasone
  • Hypothalamo-Hypophyseal System
  • Male
  • Neurons
  • Neuropeptide Y
  • Paraventricular Hypothalamic Nucleus
  • Pituitary-Adrenal System
  • Rats
  • Rats, Wistar
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Research

keywords

  • ALPHA-HELICAL CRF9-41
  • CORTICOTROPIN-RELEASING FACTOR
  • DEXAMETHASONE
  • FEEDING
  • NEUROPEPTIDE-Y
  • PARAVENTRICULAR NUCLEUS
  • RAT
  • VENTROMEDIAL HYPOTHALAMUS
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Identity

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(93)91771-j

PubMed ID

  • 8518948
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Additional Document Info

start page

  • 18

end page

  • 24

volume

  • 611

issue

  • 1

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