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A dopamine d-1 agonist elevates self-stimulation thresholds: Comparison to other dopamine-selective drugs

Academic Article
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Overview

authors

  • Baldo, B. A.
  • Jain, K.
  • Veraldi, L.
  • Koob, George
  • Markou, A.

publication date

  • April 1999

journal

  • Pharmacology, Biochemistry and Behavior  Journal

abstract

  • The effects of the high-efficacy D1 receptor agonist SKF 81297 and the D2/3 receptor agonist 7-OH-DPAT on brain stimulation reward thresholds and on response latencies in responding for the stimulation, were compared to the effects of subtype-selective receptor antagonists and a dopamine uptake blocker. SKF 81297 produced dose-dependent elevations in reward thresholds but did not alter response latencies. In contrast, 7-OH-DPAT produced inconsistent reward threshold elevations, yet dose dependently increased response latencies. Both the dopamine D1 receptor antagonist SCH 23390 and the D2 antagonist raclopride elevated reward thresholds, but only raclopride significantly increased response latencies. The dopamine uptake inhibitor GBR 12909 lowered reward thresholds and did not influence response latencies. The present results provide a clear demonstration that a selective, high-efficacy D1 receptor agonist elevates brain stimulation reward thresholds without producing performance deficits. Furthermore, it was observed that the effects upon reward measures of D1-selective compounds, but not D2/D3-selective compounds, are dissociable from their effects upon response latency in this task. These results are discussed with regard to a distinction between the effects of indirect and direct dopamine agonists on reward thresholds, a distinction that does not depend upon the subtype-selectivity of the direct agonists tested.

subject areas

  • Animals
  • Benzazepines
  • Dopamine Agents
  • Dopamine Agonists
  • Dopamine Antagonists
  • Dopamine Uptake Inhibitors
  • Dose-Response Relationship, Drug
  • Electrodes, Implanted
  • Male
  • Rats
  • Rats, Wistar
  • Receptors, Dopamine D1
  • Reward
  • Self Stimulation
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Research

keywords

  • 7-OH-DPAT
  • GBR12909
  • SCH23390
  • SKF81297
  • brain stimulation reward
  • dopamine
  • raclopride
  • response latency
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Identity

International Standard Serial Number (ISSN)

  • 0091-3057

Digital Object Identifier (DOI)

  • 10.1016/s0091-3057(98)00206-8

PubMed ID

  • 10208371
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Additional Document Info

start page

  • 659

end page

  • 672

volume

  • 62

issue

  • 4

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