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Long-term persistence and reactivation of t cell memory in the lung of mice infected with respiratory syncytial virus

Academic Article
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Overview

authors

  • Ostler, T.
  • Hussell, T.
  • Surh, Charles
  • Openshaw, P.
  • Ehl, S.

publication date

  • September 2001

journal

  • European Journal of Immunology  Journal

abstract

  • In mice acutely infected with respiratory syncytial virus (RSV), more than 20% of pulmonary CD8(+) T cells, but only 2-3% of CD8(+) T cells in the draining lymph node secreted interferon-gamma in response to a single peptide. Surprisingly, the percentage of virus-specific T cells in the lung remained at these high levels long after the acute infection. Pulmonary memory T cells were further studied in a sensitive adoptive transfer system, which allows visualizing polyclonal CD4(+) and CD8(+) virus-specific memory T cell responses. Fifty days after infection, persisting RSV-specific pulmonary T cells remained CD69(hi) CD62L(lo), but had returned to a resting memory state according to functional criteria. In the absence of neutralizing antibodies reinfection first induced cell division among virus-specific memory T cells 3 days after infection predominantly in the local lymph node. However, divided cells then rapidly accumulated in the lung without significantly increasing in the lymph node. These results suggest rapid export of reactivated cells from the lymph node to the target organ. Thus, although memory T cells can be maintained in the infected organ after a localized virus infection, amplification of a recall response appears to be most effective in organized lymphoid tissue.

subject areas

  • Adoptive Transfer
  • Animals
  • Antigens, Viral
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cells, Cultured
  • Immunologic Memory
  • Interferon-gamma
  • Kinetics
  • Lung
  • Lung Diseases
  • Lymph Nodes
  • Lymphocyte Activation
  • Mice
  • Mice, Inbred BALB C
  • Respiratory Syncytial Virus Infections
  • Respiratory Syncytial Viruses
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Research

keywords

  • CD4(+) T cell
  • CD8(+) T cell
  • lung
  • memory
  • respiratory syncytial virus
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Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/1521-4141(200109)31:9<2574::aid-immu2574>3.0.co;2-v

PubMed ID

  • 11536155
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Additional Document Info

start page

  • 2574

end page

  • 2582

volume

  • 31

issue

  • 9

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