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Local development of effector and memory t helper cells

Academic Article
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Overview

authors

  • Fazilleau, N.
  • McHeyzer-Williams, L. J.
  • McHeyzer-Williams, Michael G.

publication date

  • June 2007

journal

  • Current Opinion in Immunology  Journal

abstract

  • Clonal evolution underpins all facets of adaptive immunity. In particular, antigen-specific helper T (Th) cell development is central to high-affinity B cell immunity and protective vaccination. Dendritic cell maturation and TCR affinity-based selection mechanisms control the recruitment and effective propagation of preferred antigen-specific Th cell cohorts in local lymphoid tissue. Importantly, follicular B helper T (T(FH)) cells emerge as the specialized local effector Th cells that orchestrate the stepwise development of B cell immunity in these local environments. Recent studies also introduce the role of persistent antigen in the development of effector Th cells with evidence for long-term antigen depots that might contribute to local antigen-specific Th cell memory.

subject areas

  • Animals
  • B-Lymphocytes
  • Dendritic Cells
  • Germinal Center
  • Humans
  • Immunologic Memory
  • Lymphocyte Activation
  • Models, Immunological
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Helper-Inducer
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Identity

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2007.04.003

PubMed ID

  • 17420119
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Additional Document Info

start page

  • 259

end page

  • 267

volume

  • 19

issue

  • 3

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