Local development of effector and memory t helper cells

Academic Article

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Overview

authors

• Fazilleau, N.
• McHeyzer-Williams, L. J.
• McHeyzer-Williams, Michael G.

publication date

• 2007

journal

• Current Opinion in Immunology  Journal

abstract

• Clonal evolution underpins all facets of adaptive immunity. In particular, antigen-specific helper T (Th) cell development is central to high-affinity B cell immunity and protective vaccination. Dendritic cell maturation and TCR affinity-based selection mechanisms control the recruitment and effective propagation of preferred antigen-specific Th cell cohorts in local lymphoid tissue. Importantly, follicular B helper T (T(FH)) cells emerge as the specialized local effector Th cells that orchestrate the stepwise development of B cell immunity in these local environments. Recent studies also introduce the role of persistent antigen in the development of effector Th cells with evidence for long-term antigen depots that might contribute to local antigen-specific Th cell memory.

subject areas

• Animals
• B-Lymphocytes
• Dendritic Cells
• Germinal Center
• Humans
• Immunologic Memory
• Lymphocyte Activation
• Models, Immunological
• T-Lymphocyte Subsets
• T-Lymphocytes, Helper-Inducer

Identity

International Standard Serial Number (ISSN)

• 0952-7915

Digital Object Identifier (DOI)

• 10.1016/j.coi.2007.04.003

PubMed ID

• 17420119

Additional Document Info

start page

• 259

end page

• 267

volume

• 19

issue

• 3