Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Peripheral deletion of self-reactive b-cells

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Russell, D. M.
  • Dembic, Z.
  • Morahan, G.
  • Miller, Jfap
  • Burki, K.
  • Nemazee, David

publication date

  • November 1991

journal

  • Nature  Journal

abstract

  • B LYMPHOCYTES are key participants in the immune response because of their specificity, their ability to take up and present antigens to T cells, and their capacity to differentiate into antibody-secreting cells. To limit reactivity to self antigens, autospecific B cells can be functionally inactivated or deleted. Developing B cells that react with membrane antigens expressed in the bone marrow are deleted from the peripheral lymphocyte pool. It is important to ascertain the fate of B cells that recognize membrane autoantigens expressed exclusively on peripheral tissues because B cells in the peripheral lymphoid organs are phenotypically and functionally distinct from bone-marrow B cells. Here we show that in immunoglobulin-transgenic mice, B cells specific for major histocompatibility complex class I antigen can be deleted if they encounter membrane-bound antigen at a post-bone-marrow stage of development. This deletion may be necessary to prevent organ-specific autoimmunity.

subject areas

  • Animals
  • Autoantibodies
  • B-Lymphocytes
  • Blotting, Northern
  • Bone Marrow Cells
  • Cell Death
  • Clone Cells
  • Flow Cytometry
  • Gene Expression
  • Genes, Immunoglobulin
  • H-2 Antigens
  • Immune Tolerance
  • Immunoglobulin Idiotypes
  • Liver
  • Lymph Nodes
  • Mice
  • Mice, Transgenic
  • RNA, Messenger
  • Spleen
scroll to property group menus

Identity

PubMed Central ID

  • PMC3787863

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/354308a0

PubMed ID

  • 1956380
scroll to property group menus

Additional Document Info

start page

  • 308

end page

  • 311

volume

  • 354

issue

  • 6351

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support