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Mice cloned from olfactory sensory neurons

Academic Article
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Overview

authors

  • Eggan, E.
  • Baldwin, Kristin
  • Tackett, M.
  • Osborne, J.
  • Gogos, J.
  • Chess, A.
  • Axel, R.
  • Jaenisch, R.

publication date

  • March 2004

journal

  • Nature  Journal

abstract

  • Cloning by nuclear transplantation has been successfully carried out in various mammals, including mice. Until now mice have not been cloned from post-mitotic cells such as neurons. Here, we have generated fertile mouse clones derived by transferring the nuclei of post-mitotic, olfactory sensory neurons into oocytes. These results indicate that the genome of a post-mitotic, terminally differentiated neuron can re-enter the cell cycle and be reprogrammed to a state of totipotency after nuclear transfer. Moreover, the pattern of odorant receptor gene expression and the organization of odorant receptor genes in cloned mice was indistinguishable from wild-type animals, indicating that irreversible changes to the DNA of olfactory neurons do not accompany receptor gene choice.

subject areas

  • Animals
  • Cell Nucleus
  • Cloning, Organism
  • Embryo, Mammalian
  • Embryonic and Fetal Development
  • Gene Expression Regulation, Developmental
  • Mice
  • Nuclear Transfer Techniques
  • Olfactory Receptor Neurons
  • Oocytes
  • Polyploidy
  • Receptors, Odorant
  • Totipotent Stem Cells
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/nature02375

PubMed ID

  • 14990966
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Additional Document Info

start page

  • 44

end page

  • 49

volume

  • 428

issue

  • 6978

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