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Mosquito oostatic factor - a novel decapeptide modulating trypsin-like-enzyme biosynthesis in the midgut

Academic Article
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Overview

authors

  • Borovsky, D.
  • Carlson, D. A.
  • Griffin, Patrick
  • Shabanowitz, J.
  • Hunt, D. F.

publication date

  • September 1990

journal

  • FASEB Journal  Journal

abstract

  • A peptide that inhibits egg development in mosquitoes (oostatic factor) has been purified from the ovaries of female Aedes aegypti. The factor is a decapeptide with a molecular mass of 1047.6. The primary sequence has been determined as NH2-Tyr-Asp-Pro-Ala-Pro-Pro-Pro-Pro-Pro-Pro-COOH from mass spectra recorded on a quadrupole Fourier transform instrument. The amino acid sequence exhibits sequence correlation to mammalian, plant, and several viral proteins. Injection of synthetic analogs into mosquitoes, biting midges, flies, and fleas inhibited proteolytic enzyme biosynthesis in the midgut. Binding studies with [3H]oostatic factor indicated that the midgut epithelial cells have a factor-specific receptor.

subject areas

  • Aedes
  • Amino Acid Sequence
  • Animals
  • Chymotrypsin
  • Female
  • Intestines
  • Molecular Sequence Data
  • Oligopeptides
  • Ovary
  • Ovum
  • Protein Conformation
  • Species Specificity
  • Trypsin
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Identity

International Standard Serial Number (ISSN)

  • 0892-6638

PubMed ID

  • 2394318
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Additional Document Info

start page

  • 3015

end page

  • 3020

volume

  • 4

issue

  • 12

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