Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Sagiv, Y.
  • Bai, L.
  • Wei, D. G.
  • Agami, R.
  • Savage, P. B.
  • Teyton, Luc
  • Bendelac, A.

publication date

  • April 2007

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident lipid transfer protein involved in the biosynthesis and lipid loading of apolipoprotein B. MTP was recently suggested to directly regulate the biosynthesis of the MHC I-like, lipid antigen presenting molecule CD1d, based on coprecipitation experiments and lipid loading assays. However, we found that the major impact of MTP deficiency occurred distal to the ER and Golgi compartments. Thus, although the rates of CD1d biosynthesis, glycosylation maturation, and internalization from the cell surface were preserved, the late but essential stage of recycling from lysosome to plasma membrane was profoundly impaired. Likewise, functional experiments indicated defects of CD1d-mediated lipid presentation in the lysosome but not in the secretory pathway. These intriguing findings suggest a novel, unexpected role of MTP at a late stage of CD1d trafficking in the lysosomal compartment.

subject areas

  • Animals
  • Antigens
  • Antigens, CD1
  • Carrier Proteins
  • Cell Differentiation
  • Cell Membrane
  • Golgi Apparatus
  • Lipid Metabolism
  • Lipids
  • Lysosomes
  • Mice
  • Mice, Knockout
  • Protein Transport
  • T-Lymphocytes, Regulatory
scroll to property group menus

Identity

PubMed Central ID

  • PMC2118556

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20061568

PubMed ID

  • 17403933
scroll to property group menus

Additional Document Info

start page

  • 921

end page

  • 928

volume

  • 204

issue

  • 4

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support