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Region specific expression of nmda receptor nr1 subunit mrna in hypothalamus and pons following chronic morphine treatment

Academic Article
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Overview

authors

  • Zhu, H.
  • Jang, Choon-Gon
  • Ma, T.
  • Oh, S.
  • Rockhold, R. W.
  • Ho, I. K.

publication date

  • January 1999

journal

  • European Journal of Pharmacology  Journal

abstract

  • The NMDA receptor has been implicated in opioid tolerance and physical dependence. Using in situ hybridization techniques, the effects of chronic morphine treatment on the expression of mRNAs encoding the NMDA receptor subunits NRI, NR2A, and NR2B were investigated. A significant increase in the level of the NR1 subunit mRNA was found in the locus coeruleus and the hypothalamic paraventricular nucleus following 3 days of intracerebroventricular (i.c.v.) morphine infusion (26 nmol microl(-1) h(-1)) through osmotic minipumps. No changes were detected in expression of the NRI mRNA in the frontal cortex, caudate-putamen, nucleus accumbens, amygdala, CA1, CA2, and the dentate gyrus of the hippocampus, and in the central grey after morphine treatment. The expression of NR2A and NR2B subunit mRNAs did not change after morphine treatment in any brain region. These results suggest that changes in gene expression of the NRI subunit of the NMDA receptor are involved in the development of morphine tolerance and dependence.

subject areas

  • Analgesics, Opioid
  • Animals
  • Brain Stem
  • Diencephalon
  • Gene Expression Regulation
  • Hippocampus
  • Hypothalamus
  • In Situ Hybridization
  • Male
  • Morphine
  • Pons
  • Prosencephalon
  • RNA, Messenger
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, N-Methyl-D-Aspartate
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Research

keywords

  • NMDA receptor
  • in situ hybridization
  • morphine
  • physical dependence
  • tolerance
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Identity

International Standard Serial Number (ISSN)

  • 0014-2999

Digital Object Identifier (DOI)

  • 10.1016/s0014-2999(98)00861-9

PubMed ID

  • 9988122
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Additional Document Info

start page

  • 47

end page

  • 54

volume

  • 365

issue

  • 1

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