recent publications

• academic article

  • Avvaru, B. S., Busby, S. A., Chalmers, M. J., Griffin, P. R., Venkatakrishnan, B., Agbandje-McKenna, M., Silverman, D. N., McKenna, R. Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network Biochemistry  2009 48:7365-7372  DOI:10.1021/bi9007512  PMID:19583303  PMCID:PMC2762735
  • Perry, J. J. P., Hearn, A. S., Cabelli, D. E., Nick, H. S., Tainer, J. A., Silverman, D. N. Contribution of human manganese superoxide dismutase tyrosine 34 to structure and catalysis Biochemistry  2009 48:3417-3424  DOI:10.1021/bi8023288  PMID:19265433  PMCID:PMC2756076
  • Ren, X. L., Tu, C. K., Bhatt, D., Perry, J. J. P., Tainer, J. A., Cabelli, D. E., Silverman, D. N. Kinetic and structural characterization of human manganese superoxide dismulase containing 3-fluorotyrosines Journal of Molecular Structure  2006 790:168-173  DOI:10.1016/j.molstruc.2005.10.054
  • Quint, P., Ayala, I., Busby, S. A., Chalmers, M. J., Griffin, P. R., Rocca, J., Nick, H. S., Silverman, D. N. Structural mobility in human manganese superoxide dismutase Biochemistry  2006 45:8209-8215  DOI:10.1021/bi0606288  PMID:16819819
  • Ayala, I., Perry, J. J. P., Szczepanski, J., Tainer, J. A., Vala, M. T., Nick, H. S., Silverman, D. N. Hydrogen bonding in human manganese superoxide dismutase containing 3-fluorotyrosine Biophysical Journal  2005 89:4171-4179  DOI:10.1529/biophysj.105.060616  PMID:16150974  PMCID:PMC1366982
  • Hearn, A. S., Fan, L., Lepock, J. R., Luba, J. P., Greenleaf, W. B., Cabelli, D. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Amino acid substitution at the dimeric interface of human manganese superoxide dismutase Journal of Biological Chemistry  2004 279:5861-5866  DOI:10.1074/jbc.M311310200  PMID:14638684
  • Greenleaf, W. B., Jefferson, J., Perry, P., Hearn, A. S., Cabelli, D. E., Lepock, J. R., Stroupe, M. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Role of hydrogen bonding in the active site of human manganese superoxide dismutase Biochemistry  2004 43:7038-7045  DOI:10.1021/bi049888k  PMID:15170341
  • Hearn, A. S., Stroupe, M. E., Cabelli, D. E., Ramilo, C. A., Luba, J. P., Tainer, J. A., Nick, H. S., Silverman, D. N. Catalytic and structural effects of amino acid substitution at histidine 30 in human manganese superoxide dismutase: Insertion of valine Cγ into the substrate access channel Biochemistry  2003 42:2781-2789  DOI:10.1021/bi0266481  PMID:12627943
  • Hearn, A. S., Stroupe, M. E., Cabelli, D. E., Lepock, J. R., Tainer, J. A., Nick, H. S., Silverman, D. N. Kinetic analysis of product inhibition in human manganese superoxide dismutase Biochemistry  2001 40:12051-12058  DOI:10.1021/bi011047f  PMID:11580280
  • Leveque, V. J. P., Stroupe, M. E., Lepock, J. R., Cabelli, D. E., Tainer, J. A., Nick, H. S., Silverman, D. N. Multiple replacements of glutamine 143 in human manganese superoxide dismutase: Effects on structure, stability, and catalysis Biochemistry  2000 39:7131-7137  DOI:10.1021/bi9929958  PMID:10852710
  • Ramilo, C. A., Leveque, V., Guan, Y., Lepock, J. R., Tainer, J. A., Nick, H. S., Silverman, D. N. Interrupting the hydrogen bond network at the active site of human manganese superoxide dismutase Journal of Biological Chemistry  1999 274:27711-27716  DOI:10.1074/jbc.274.39.27711  PMID:10488113
  • Cabelli, D. E., Guan, Y., Leveque, V., Hearn, A. S., Tainer, J. A., Nick, H. S., Silverman, D. N. Role of tryptophan 161 in catalysis by human manganese superoxide dismutase Biochemistry  1999 38:11686-11692  DOI:10.1021/bi9909142  PMID:10512624
  • Guan, Y., Hickey, M. J., Borgstahl, G. E. O., Hallewell, R. A., Lepock, J. R., O'Connor, D., Hsieh, Y. S., Nick, H. S., Silverman, D. N., Tainer, J. A. Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34 Biochemistry  1998 37:4722-4730  DOI:10.1021/bi972394l  PMID:9537987
  • Hsieh, Y. S., Guan, Y., Tu, C. K., Bratt, P. J., Angerhofer, A., Lepock, J. R., Hickey, M. J., Tainer, J. A., Nick, H. S., Silverman, D. N. Probing the active site of human manganese superoxide dismutase: The role of glutamine 143 Biochemistry  1998 37:4731-4739  DOI:10.1021/bi972395d  PMID:9537988
  • Tu, C. K., Chen, X., Ren, X. L., Lograsso, P. V., Jewell, D. A., Laipis, P. J., Silverman, D. N. Interactions of active-site residues and catalytic activity of human carbonic anhydrase III Journal of Biological Chemistry  1994 269:23002-23006  PMID:8083199
  • Lograsso, P. V., Tu, C. K., Chen, X., Taoka, S. C., Laipis, P. J., Silverman, D. N. Influence of amino acid replacement at position 198 on catalytic properties of zinc-bound water in human carbonic anhydrase III Biochemistry  1993 32:5786-5791  DOI:10.1021/bi00073a010  PMID:8504098
  • Chen, X., Tu, C. K., Lograsso, P. V., Laipis, P. J., Silverman, D. N. Interaction and influence of phenylalanine-198 and threonine-199 on catalysis by human carbonic anhydrase III Biochemistry  1993 32:7861-7865  DOI:10.1021/bi00082a004  PMID:8347590
  • Lograsso, P. V., Tu, C. K., Jewell, D. A., Wynns, G. C., Laipis, P. J., Silverman, D. N. Catalytic enhancement of human carbonic anhydrase III by replacement of phenylalanine-198 with leucine Biochemistry  1991 30:8463-8470  DOI:10.1021/bi00098a025  PMID:1909176
  • Jewell, D. A., Tu, C. K., Paranawithana, S. R., Tanhauser, S. M., Lograsso, P. V., Laipis, P. J., Silverman, D. N. Enhancement of the catalytic properties of human carbonic anhydrase-iii by site-directed mutagenesis Biochemistry  1991 30:1484-1490  DOI:10.1021/bi00220a006  PMID:1899618
  • Tu, C. K., Paranawithana, S. R., Jewell, D. A., Tanhauser, S. M., Lograsso, P. V., Wynns, G. C., Laipis, P. J., Silverman, D. N. Buffer enhancement of proton-transfer in catalysis by human carbonic anhydrase-iii Biochemistry  1990 29:6400-6405  DOI:10.1021/bi00479a009  PMID:2169869