Mri detection of vegfr2 in vivo using a low molecular weight peptoid-(gd)(8)-dendron for targeting

Academic Article
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publication date

  • 2010

abstract

  • The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo.