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Mri detection of vegfr2 in vivo using a low molecular weight peptoid-(gd)(8)-dendron for targeting

Academic Article
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Overview

authors

  • De Leon-Rodriguez, L. M.
  • Lubag, A.
  • Udugamasooriya, D. G.
  • Proneth, B.
  • Brekken, R. A.
  • Sun, X. K.
  • Kodadek, Thomas
  • Sherry, A. D.

publication date

  • September 2010

journal

  • Journal of the American Chemical Society  Journal

abstract

  • The synthesis of a polylysine dendron containing eight GdDOTA units conjugated to a peptoid dimer known to have a high affinity for the vascular endothelial growth factor receptor 2 (VEGFR2) is described. This simple low molecular weight system with a molecular r(1) relaxivity of ∼48 mM(-1) s(-1) is shown to enhance MR images of tumors grown in mice in vivo.

subject areas

  • Animals
  • Anthracenes
  • Cell Line, Tumor
  • Gadolinium
  • Humans
  • Magnetic Resonance Imaging
  • Mice
  • Mice, Nude
  • Molecular Weight
  • Peptoids
  • Vascular Endothelial Growth Factor Receptor-2
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Identity

PubMed Central ID

  • PMC2967214

International Standard Serial Number (ISSN)

  • 0002-7863

Digital Object Identifier (DOI)

  • 10.1021/ja105563a

PubMed ID

  • 20795620
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Additional Document Info

start page

  • 12829

end page

  • 12831

volume

  • 132

issue

  • 37

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