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The human carcinoma cell-line a431 possesses large numbers of functional beta-adrenergic receptors

Academic Article
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Overview

authors

  • Delavierklutchko, C.
  • Hoebeke, J.
  • Strosberg, Donny

publication date

  • 1984

journal

  • FEBS Letters  Journal

abstract

  • The existence of beta-adrenergic receptors was demonstrated on whole A431 cells as well as A431 membrane preparations by means of binding assays using the hydrophobic 1-[3H]dihydroalprenolol and the hydrophilic antagonist [3H]CGP-12,177 as beta-adrenergic ligands. Binding was stereospecific. The receptors, as shown by competition studies, proved to be of the beta 2-subtype and appeared functional in the stimulation of adenylate cyclase. The number of receptors per cell and the yield of receptor sites/mg membrane protein render the A431 cell a useful tool for the study of human beta-adrenergic receptors.

subject areas

  • Adrenergic beta-Antagonists
  • Binding, Competitive
  • Carcinoma, Squamous Cell
  • Cell Line
  • Dihydroalprenolol
  • Humans
  • Isoproterenol
  • Propanolamines
  • Propranolol
  • Receptors, Adrenergic, beta
  • Stereoisomerism
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Identity

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/0014-5793(84)80308-7

PubMed ID

  • 6143691
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Additional Document Info

start page

  • 151

end page

  • 155

volume

  • 169

issue

  • 2

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